β-Blockers Improve Presinusoidal Portal Hypertension

被引：13

作者：

Sorensen, Michael ^{[1
]}

Larsen, Lars P. ^{[2
]}

Villadsen, Gerda E. ^{[1
]}

Aagaard, Niels K. ^{[1
]}

Gronbaek, Henning ^{[1
]}

Keiding, Susanne ^{[1
]}

Vilstrup, Hendrik ^{[1
]}

机构：

[1] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Palle Juul Jensens Blvd 99,C116, DK-8000 Aarhus, Denmark

[2] Aarhus Univ Hosp, Dept Radiol, DK-8000 Aarhus, Denmark

来源：

DIGESTIVE DISEASES AND SCIENCES | 2018年 / 63卷 / 11期

关键词：

Gastroesophageal varices; Non-cirrhotic portal hypertension; Portal vein thrombosis; Splenic vein thrombosis; Propranolol; SPLENIC VEIN-THROMBOSIS; PRESSURE; PROPRANOLOL; VARICES; MANAGEMENT; RESISTANCE; DIAGNOSIS; CIRRHOSIS;

D O I：

10.1007/s10620-018-5186-1

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BackgroundPresinusoidal portal hypertension is a clinically important cause of gastric and gastroesophageal varices. Whereas -blockers have an established prophylactic role against bleeding from esophageal and gastric varices in portal hypertension due to cirrhosis, the effect on presinusoidal portal hypertension is unknown.AimsTo evaluate the hemodynamic effect of -blockers in non-cirrhotic patients with presinusoidal portal hypertension.MethodsWe measured the blood pressure gradient from spleen pulp to free hepatic vein in 12 patients with presinusoidal portal hypertension by combined hepatic vein catheterization and spleen pulp puncture while on and off -blocker treatment (random sequence).ResultsThe -blockers reduced the gradient from a mean off-treatmentvalue of 32mmHg to a on-treatment value of26mmHg (P<0.05) with a reduction of at least 20% in five patients (42%).Conclusions-blocker treatment caused a clinically significant reduction in the pressure gradient from spleen pulp to the free hepatic vein. This finding supports the recommendation for prophylactic -blockage in patients with presinusoidal portal hypertension.

引用

页码：3153 / 3157

页数：5

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