Reduction in HPV16/18 prevalence among young women with high-grade cervical lesions following the Japanese HPV vaccination program

被引：28

作者：

Matsumoto, Koji ^{[1
]}

Yaegashi, Nobuo ^{[2
]}

Iwata, Takashi ^{[3
]}

Yamamoto, Kasumi ^{[4
]}

Aoki, Yoichi ^{[5
,14
]}

Okadome, Masao ^{[6
]}

Ushijima, Kimio ^{[7
]}

Kamiura, Shoji ^{[8
]}

Takehara, Kazuhiro ^{[9
]}

Horie, Koji ^{[10
]}

Tasaka, Nobutaka ^{[11
]}

Sonoda, Kenzo ^{[12
]}

Takei, Yuji ^{[13
]}

Aoki, Yoichi ^{[5
,14
]}

Konnai, Katsuyuki ^{[15
]}

Katabuchi, Hidetaka ^{[16
]}

Nakamura, Keiichiro ^{[17
]}

Ishikawa, Mitsuya ^{[18
]}

Watari, Hidemichi ^{[19
,20
]}

Yoshida, Hiroyuki ^{[21
]}

Matsumura, Noriomi ^{[22
,23
]}

Nakai, Hidekatsu ^{[23
]}

Shigeta, Shogo ^{[2
]}

Takahashi, Fumiaki ^{[24
]}

Noda, Kiichiro ^{[25
]}

Yoshikawa, Hiroyuki ^{[11
]}

机构：

[1] Showa Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Obstet & Gynecol, Sendai, Miyagi, Japan

[3] Keio Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan

[4] Hyogo Canc Ctr, Gynecol Oncol, Akashi, Hyogo, Japan

[5] Canc Inst Hosp, Dept Gynecol, Tokyo, Japan

[6] NHO Kyushu Canc Ctr, Gynecol Serv, Fukuoka, Fukuoka, Japan

[7] Kurume Univ, Sch Med, Dept Obstet & Gynecol, Kurume, Fukuoka, Japan

[8] Osaka Int Canc Inst, Dept Gynecol, Osaka, Japan

[9] Natl Hosp Org Shikoku Canc Ctr, Dept Gynecol Oncol, Matsuyama, Ehime, Japan

[10] Saitama Canc Ctr, Dept Gynecol, Saitama, Japan

[11] Univ Tsukuba, Fac Med, Dept Obstet & Gynecol, Tsukuba, Ibaraki, Japan

[12] Kyushu Univ, Grad Sch Med Sci, Dept Gynecol & Obstet, Fukuoka, Fukuoka, Japan

[13] Jichi Med Univ, Dept Obstet & Gynecol, Shimotsuke, Tochigi, Japan

[14] Univ Ryukyus, Grad Sch Med, Dept Obstet & Gynecol, Nishihara, Okinawa, Japan

[15] Kanagawa Canc Ctr, Dept Gynecol, Yokohama, Kanagawa, Japan

[16] Kumamoto Univ, Fac Life Sci, Dept Obstet & Gynecol, Kumamoto, Japan

[17] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Obstet & Gynecol, Okayama, Japan

[18] Natl Canc Ctr, Dept Gynecol, Tokyo, Japan

[19] Hokkaido Univ, Grad Sch Med, Dept Obstet & Gynecol, Sapporo, Hokkaido, Japan

[20] Fac Med, Sapporo, Hokkaido, Japan

[21] Saitama Med Univ, Int Med Ctr, Dept Gynecol Oncol, Saitama, Japan

[22] Kyoto Univ, Grad Sch Med, Dept Gynecol & Obstet, Kyoto, Japan

[23] Kindai Univ, Fac Med, Dept Obstet & Gynecol, Osaka, Japan

[24] Iwate Med Univ, Dept Informat Sci, Div Med Engn, Morioka, Iwate, Japan

[25] Kindai Univ, Osaka, Japan

来源：

CANCER SCIENCE | 2019年 / 110卷 / 12期

关键词：

adenocarcinoma in situ; cervical cancer; cervical intraepithelial neoplasia; human papillomavirus; vaccination; HUMAN-PAPILLOMAVIRUS VACCINATION; ABNORMALITIES; ASSOCIATION; INFECTION; NEOPLASIA; EFFICACY; HEALTH;

D O I：

10.1111/cas.14212

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Japanese government began a human papillomavirus (HPV) vaccination program for girls aged 12-16 years in 2010 but withdrew its recommendation in 2013 because of potential adverse effects, leading to drastically reduced vaccination uptake. To evaluate population-level effects of HPV vaccination, women younger than 40 years of age newly diagnosed with cervical intraepithelial neoplasia grade 1-3 (CIN1-3), adenocarcinoma in situ (AIS), or invasive cervical cancer (ICC) have been registered at 21 participating institutes each year since 2012. A total of 7709 women were registered during 2012-2017, of which 5045 were HPV genotyped. Declining trends in prevalence of vaccine types HPV16 and HPV18 during a 6-year period were observed in CIN1 (50.0% to 0.0%, P-trend < .0001) and CIN2-3/AIS (83.3% to 45.0%, P-trend = .07) only among women younger than 25 years of age. Overall, HPV vaccination reduced the proportion of HPV16/18-attributable CIN2-3/AIS from 47.7% to 33.0% (P = .003): from 43.5% to 12.5% as routine vaccination (P = .08) and from 47.8% to 36.7% as catch-up vaccination (P = .04). The HPV16/18 prevalence in CIN2-3/AIS cases was significantly reduced among female individuals who received their first vaccination at age 20 years or younger (P = .02). We could not evaluate vaccination effects on ICC owing to low incidence of ICC among women aged less than 25 years. We found HPV vaccination to be effective in protecting against HPV16/18-positive CIN/AIS in Japan; however, our data did not support catch-up vaccination for women older than 20 years. Older adolescents who skipped routine vaccination due to the government's suspension of its vaccine recommendation could benefit from receiving catch-up vaccination before age 20 years.

引用

页码：3811 / 3820

页数：10

共 26 条

[1]

[Anonymous], BMJ

[2] Early effect of the HPV vaccination programme on cervical abnormalities in Victoria, Australia: an ecological study [J].

Brotherton, Julia M. L. ;

Fridman, Masha ;

May, Cathryn L. ;

Chappell, Genevieve ;

Saville, A. Marion ;

Gertig, Dorota M. .

LANCET, 2011, 377 (9783) :2085-2092

[3] Effectiveness of quadrivalent human papillomavirus vaccine for the prevention of cervical abnormalities: case-control study nested within a population based screening programme in Australia [J].

Crowe, Elizabeth ;

Pandeya, Nirmala ;

Brotherton, Julia M. L. ;

Dobson, Annette J. ;

Kisely, Stephen ;

Lambert, Stephen B. ;

Whiteman, David C. .

BMJ-BRITISH MEDICAL JOURNAL, 2014, 348

[4] Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis [J].

Drolet, Melanie ;

Benard, Elodie ;

Perez, Norma ;

Brisson, Marc ;

Boily, Marie-Claude ;

Ali, Hammad ;

Baldo, Vincenzo ;

Brassard, Paul ;

Brotherton, Julia M. L. ;

Callander, Denton ;

Checchi, Marta ;

Chow, Eric P. F. ;

Cocchio, Silvia ;

Dalianis, Tina ;

Deeks, Shelley L. ;

Dehlendorff, Christian ;

Donovan, Basil ;

Fairley, Christopher K. ;

Flagg, Elaine W. ;

Gargano, Julia W. ;

Garland, Suzanne M. ;

Grun, Nathalie ;

Hansen, Bo T. ;

Harrison, Christopher ;

Herweijer, Eva ;

Imburgia, Teresa M. ;

Johnson, Anne M. ;

Kahn, Jessica A. ;

Kavanagh, Kimberley ;

Kjaer, Susanne K. ;

Kliewer, Erich V. ;

Liu, Bette ;

Machalek, Dorothy A. ;

Markowitz, Lauri ;

Mesher, David ;

Munk, Christian ;

Niccolai, Linda ;

Nygard, Mari ;

Ogilvie, Gina ;

Oliphant, Jeannie ;

Pollock, Kevin G. ;

Purrinos-Hermida, Maria Jesus ;

Smith, Megan A. ;

Steben, Marc ;

Soderlund-Strand, Anna ;

Sonnenberg, Pam ;

Sparen, Par ;

Tanton, Clare ;

Wheeler, Cosette M. ;

Woestenberg, Petra J. .

LANCET, 2019, 394 (10197) :497-509

[5] Final analysis of a study assessing genital human papillomavirus genoprevalence in young Australian women, following eight years of a national vaccination program [J].

Garland, Suzanne M. ;

Cornall, Alyssa M. ;

Brotherton, Julia M. L. ;

Wark, John D. ;

Malloy, Michael J. ;

Tabrizi, Sepehr N. .

VACCINE, 2018, 36 (23) :3221-3230

[6] HPV vaccination crisis in Japan [J].

Hanley, Sharon J. B. ;

Yoshioka, Eiji ;

Ito, Yoshiya ;

Kishi, Reiko .

LANCET, 2015, 385 (9987) :2571-2571

[7] A 9-Valent HPV Vaccine against Infection and Intraepithelial Neoplasia in Women [J].

Joura, E. A. ;

Giuliano, A. R. ;

Iversen, O-E ;

Bouchard, C. ;

Mao, C. ;

Mehlsen, J. ;

Moreira, E. D., Jr. ;

Ngan, Y. ;

Petersen, L. K. ;

Lazcano-Ponce, E. ;

Pitisuttithum, P. ;

Restrepo, J. A. ;

Stuart, G. ;

Woelber, L. ;

Yang, Y. C. ;

Cuzick, J. ;

Garland, S. M. ;

Huh, W. ;

Kjaer, S. K. ;

Bautista, O. M. ;

Chan, I. S. F. ;

Chen, J. ;

Gesser, R. ;

Moeller, E. ;

Ritter, M. ;

Vuocolo, S. ;

Luxembourg, A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (08) :711-723

[8] Changes in the prevalence of human papillomavirus following a national bivalent human papillomavirus vaccination programme in Scotland: a 7-year cross-sectional study [J].

Kavanagh, Kimberley ;

Pollock, Kevin G. ;

Cuschieri, Kate ;

Palmer, Tim ;

Cameron, Ross L. ;

Watt, Cameron ;

Bhatia, Ramya ;

Moore, Catherine ;

Cubie, Heather ;

Cruickshank, Margaret ;

Robertson, Chris .

LANCET INFECTIOUS DISEASES, 2017, 17 (12) :1293-1302

[9] Guidelines for office gynecology in Japan: Japan Society of Obstetrics and Gynecology (JS']JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2017 edition [J].

Kawaguchi, Ryuji ;

Matsumoto, Koji ;

Akira, Shigeo ;

Ishitani, Ken ;

Iwasaku, Kazuhiro ;

Ueda, Yutaka ;

Okagaki, Ryugo ;

Okano, Hiroya ;

Oki, Toshimichi ;

Koga, Kaori ;

Kido, Michiko ;

Kurabayashi, Takumi ;

Kuribayashi, Yasushi ;

Sato, Yuichi ;

Shiina, Kaori ;

Takai, Yasushi ;

Tanimura, Satoshi ;

Chaki, Osamu ;

Terauchi, Masakazu ;

Todo, Yukiharu ;

Noguchi, Yasuyuki ;

Nose-Ogura, Sayaka ;

Baba, Tsukasa ;

Hirasawa, Akira ;

Fujii, Takuma ;

Fujii, Tsuneo ;

Maruyama, Tetsuo ;

Miyagi, Etsuko ;

Yanagida, Kaoru ;

Yoshino, Osamu ;

Iwashita, Mitsutoshi ;

Maeda, Tsugio ;

Minegishi, Takashi ;

Kobayashi, Hiroshi .

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2019, 45 (04) :766-786

[10] Effectiveness of HPV vaccination against high grade cervical lesions in Japan [J].

Konno, Ryo ;

Konishi, Hiroshi ;

Sauvaget, Catherine ;

Ohashi, Yasuo ;

Kakizoe, Tadao .

VACCINE, 2018, 36 (52) :7913-7915

← 1 2 3 →