Direct catalytic asymmetric aldol reactions on chiral catalysts assembled in the interface of emulsion droplets

被引：72
|
作者：
Zhong, Lin
Gao, Qiang
Gao, Jinbo
Xiao, Jianliang
Li, Can [1 ]
机构：
[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
[2] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England
来源：
JOURNAL OF CATALYSIS | 2007年 / 250卷 / 02期
基金：
中国国家自然科学基金;
关键词：
aldol reaction; asymmetric synthesis; emulsion catalysis; interface;
D O I：
10.1016/j.jcat.2007.06.017
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An amphiphilic proline-based organocatalyst was assembled on the interface of water and oil, resulting in a W/O emulsion. The chiral catalyst in emulsion significantly enhances the reactivity and stereoselectivity of the direct asymmetric aldol reactions, which can be attributed mainly to the larger interfacial surface area and uniformly distributed catalyst molecules in the interface of the emulsion droplets. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：360 / 364
页数：5
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