Immune-based prevention of mother-to-child HIV-1 transmission

被引：0

作者：

Gray, Glenda E. ^{[1
]}

Tiemessen, Caroline T.

de Bruyn, Guy

机构：

[1] Univ Witwatersrand, Perinatal HIV Res Unit, Chris Hano Baragwanath Hosp Soweto, Johannesburg, South Africa

[2] Natl Inst Communicable Dis, Johannesburg, South Africa

来源：

CURRENT OPINION IN MOLECULAR THERAPEUTICS | 2007年 / 9卷 / 02期

基金：

英国惠康基金;

关键词：

antibodies; HIV; perinatal; vaccine; vertical transmission;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Vertical transmission, or mother-to-child transmission (MTCT), is the main mode of HIV-1 acquisition in infants and children. The presence of passively transferred maternal antibodies to HIV-1 has not protected infants from HIV-1 infection and there is no clear understanding about the role of antibodies in preventing MTCT. Immune factors, such as leukemia inhibitory factor, CC chemokines, Lewis X component and secretory leukocyte protease inhibitor, appear to be involved in the protection of HIV-exposed, uninfected infants. The mainstay of reducing HIV transmission risk in infants remains the use of antiretroviral therapy. Future strategies to augment the role of antiretrovirals in preventing MTCT, or to target the prevention of transmission through breastfeeding, may include the use of vaccination and/or passive immunization with neutralizing monoclonal antibodies.

引用

页码：168 / 175

页数：8

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