Hepatitis B: future curative strategies

被引：25

作者：

Bertoletti, Antonio ^{[1
,2
,3
]}

Rivino, Laura ^{[1
]}

机构：

[1] Duke NUS Med Sch, Program Emerging Infect Dis, Singapore, Singapore

[2] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore

[3] Univ Birmingham, Coll Med & Dent Sci, Sch Immun & Infect, Edgbaston Birmingham, W Midlands, England

来源：

CURRENT OPINION IN INFECTIOUS DISEASES | 2014年 / 27卷 / 06期

关键词：

chronic hepatitis B; toll-like receptor-agonist; vaccine therapy; CD8(+) T-CELLS; HEPATOCELLULAR-CARCINOMA; VIRUS-REPLICATION; IMMUNE-RESPONSES; MOUSE MODEL; IN-VIVO; HBV; VACCINE; IMMUNOTHERAPY; ANTIGEN;

D O I：

10.1097/QCO.0000000000000110

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose of reviewHepatitis B virus (HBV) causes a large proportion of chronic liver disease worldwide. The limited efficiency of current treatments based on the use of nucleotide/nucleoside analogues or interferon-alpha requires the development of new therapeutic tools for the treatment of chronic HBV. We summarize the most recent therapeutic strategies designed to directly target HBV-infected hepatocytes or to restore antiviral immunity during chronic HBV infection.Recent findingsNovel therapies directly target HBV-infected hepatocytes by inducing covalently closed circular DNA degradation or by inhibiting HBV entry or the expression of viral proteins. In addition, immunotherapeutic approaches may boost HBV-specific T-cell responses or stimulate the intrahepatic innate response.SummaryThese new therapeutic approaches have mainly been tested in animal models. In humans, therapeutic strategies could be tailored to different chronic HBV patients in relation to their clinical and virological disease profile.

引用

页码：528 / 534

页数：7

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