Brain-derived neurotrophic factor: a bridge between major depression and Alzheimer's disease?

被引：51
作者：
Tsai, SJ
机构：
[1] Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan
[2] Natl Yang Ming Univ, Taipei 112, Taiwan
来源：
MEDICAL HYPOTHESES | 2003年 / 61卷 / 01期
关键词：
D O I：
10.1016/S0306-9877(03)00141-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Cognitive impairment is common in major depression (MD) patients, with these individuals incurring increased risk for development of Alzheimer's disease (AD). Further, depressive symptoms are common in AD patients. This apparent convergence suggests pathogenic factors common to AD and MD. Since decreased brain-derived neurotrophic factor (BDNF), a member of the neurotrophic factor family, is related to both AD and MD, the author suggests that BDNF could be a bridge between AD and MID, explaining both the depressive symptoms in AD, and, cognitive impairment in MD. Evidence supporting this hypothesis suggests that early antidepressants treatment for aged MID patients may decrease the risk of AD, and agents that increase central BDNF may offer an alternative treatment for MD patients with cognitive impairment and/or for AD sufferers with depressive symptoms. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：110 / 113
页数：4
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