Roles of the matrix metalloproteinases in mammary gland development and cancer

被引：113

作者：

Benaud, C

Dickson, RB

Thompson, EW

机构：

[1] Georgetown Univ, Med Ctr, Vincent T Lombardi Canc Res Ctr, Dept Pharmacol, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Dept Cell Biol, Washington, DC 20007 USA

[3] Georgetown Univ, Med Ctr, Dept Orthoped Surg, Washington, DC 20007 USA

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1998年 / 50卷 / 02期

关键词：

MMP; breast development; breast cancer;

D O I：

10.1023/A:1006061115909

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tissue remodeling is a key process involved in normal development, wound healing, bone remodeling, and embryonic implantation, as well as pathological conditions such as tumor invasion and metastasis, and angiogenesis. The degradation of the extracellular matrix that is associated with those processes is mediated by a number of families of extracellular proteinases. These families include the serine proteinases, such as the plasminogen-urokinase plasminogen activator system and leukocyte elastases, the cysteine proteinases, like cathepsin D and L, and the zinc-dependent matrix metalloproteinases (MMPs) [1]. Accumulating evidence has highlighted the central role of MMP-driven extracellular matrix remodeling in mammary gland development and breast cancer.

引用

页码：97 / 116

页数：20

共 144 条

[1] MATRIX METALLOPROTEINASE-2 IS AN INTERSTITIAL COLLAGENASE - INHIBITOR-FREE ENZYME CATALYZES THE CLEAVAGE OF COLLAGEN FIBRILS AND SOLUBLE NATIVE TYPE-I COLLAGEN GENERATING THE SPECIFIC 3/4-LENGTH AND 1/4-LENGTH FRAGMENTS [J].