Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas

被引：56

作者：

Handra-Luca, A. ^{[1
,2
]}

Hong, S-M ^{[1
]}

Walter, K. ^{[1
]}

Wolfgang, C. ^{[3
]}

Hruban, R. ^{[1
,4
]}

Goggins, M. ^{[1
,4
,5
]}

机构：

[1] Johns Hopkins Med Inst, Dept Pathol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[2] Univ Paris 13, Nord Med APHP, UFR SMBH, Paris, France

[3] Johns Hopkins Med Inst, Dept Surg, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[4] Johns Hopkins Med Inst, Dept Med, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

[5] Johns Hopkins Med Inst, Dept Oncol, Sol Goldman Pancreat Canc Res Ctr, Baltimore, MD 21205 USA

来源：

BRITISH JOURNAL OF CANCER | 2011年 / 104卷 / 08期

关键词：

pancreas; adenocarcinoma; prognosis; vimentin; MESENCHYMAL TRANSITION; DIFFERENTIATION MARKERS; CADHERIN EXPRESSION; CELL CARCINOMAS; POOR-PROGNOSIS; CANCER; METHYLATION; CHEMOTHERAPY; ADHESION; TARGET;

D O I：

10.1038/bjc.2011.93

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PURPOSE: Tumour epithelial vimentin expression is a marker of mesenchymal differentiation and may be a useful marker of carcinomas with more aggressive behaviour. The aim of this study was to determine the extent and prognostic significance of vimentin expression in pancreatic ductal adenocarcinomas. METHODS: Vimentin expression was detected by immunohistochemistry on tissue microarrays of surgically resected pancreatic ductal adenocarcinomas from 387 patients. The percentage of vimentin-immunolabelled neoplastic cells was correlated with outcome and with clinico-pathological factors using the Kaplan-Meier method and Cox multivariate survival models. RESULTS: In all, 45% of primary pancreatic adenocarcinomas contained neoplastic cells that expressed vimentin, and in 27.5% of the cancers >10% of cells expressed vimentin. Vimentin expression was correlated with poor histological differentiation. By both uni- and multivariate survival analysis, neoplastic vimentin expression (P<0.01, HR 1.52, 95% confidence interval 1.14-2.04) was an indicator of a shorter postsurgical survival independent of other clinico-pathological variables. CONCLUSION: The presence of vimentin-expressing tumour epithelial cells in surgically resected pancreatic adenocarcinomas independently predicted a shorter postsurgical survival. British Journal of Cancer (2011) 104, 1296-1302. doi:10.1038/bjc.2011.93 www.bjcancer.com Published online 29 March 2011 (C) 2011 Cancer Research UK

引用

页码：1296 / 1302

页数：7

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