Alopecia areata in patients with systemic lupus erythematosus treated with belimumab: a plausible association

被引:2
作者
Shamriz, O. [1 ,2 ]
Yahia, S. H. [3 ,4 ]
Ramot, Y. [5 ]
Agmon-Levin, N. [3 ,4 ]
Tal, Y. [1 ]
机构
[1] Hadassah Hebrew Univ Med Ctr, Allergy & Clin Immunol Unit, Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Immunol & Canc Res, Jerusalem, Israel
[3] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel
[4] Clin Immunol Angioedema & Allergy Unit, Tel Hashomer, Israel
[5] Hadassah Med Ctr, Dept Dermatol, Jerusalem, Israel
关键词
Alopecia areata; belimumab; SLE; systemic lupus erythematosus;
D O I
10.1177/0961203319899985
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Belimumab, an anti-B-lymphocyte stimulator monoclonal antibody, was recently approved for the treatment of systemic lupus erythematosus. Alopecia areata is characterized by an acute immune-mediated hair loss. Herein, we report on three adult systemic lupus erythematosus patients who developed alopecia areata in association with belimumab treatment. Alopecia areata was resolved in all three patients and belimumab was discontinued in two of them. Thus, in the current report, we explore the plausible link between alopecia areata and belimumab.
引用
收藏
页码:426 / 430
页数:5
相关论文
共 10 条
[1]   Alopecias in lupus erythematosus [J].
Concha, Josef Symon Salgado ;
Werth, Victoria P. .
LUPUS SCIENCE & MEDICINE, 2018, 5 (01)
[2]   Follicular CD4 T Cells Tutor CD8 Early Memory Precursors: An Initiatory Journey to the Frontier of B Cell Territory [J].
de Herve, Marie-Ghislaine de Goer ;
Abdoh, Maisa ;
Jaafoura, Salma ;
Durali, Deniz ;
Taoufik, Yassine .
ISCIENCE, 2019, 20 :100-+
[3]   2019 update of the EULAR recommendations for the management of systemic lupus erythematosus [J].
Fanouriakis, Antonis ;
Kostopoulou, Myrto ;
Alunno, Alessia ;
Aringer, Martin ;
Bajema, Ingeborg ;
Boletis, John N. ;
Cervera, Ricard ;
Doria, Andrea ;
Gordon, Caroline ;
Govoni, Marcello ;
Houssiau, Frederic ;
Jayne, David ;
Kouloumas, Marios ;
Kuhn, Annegret ;
Larsen, Janni L. ;
Lerstrom, Kirsten ;
Moroni, Gabriella ;
Mosca, Marta ;
Schneider, Matthias ;
Smolen, Josef S. ;
Svenungsson, Elisabet ;
Tesar, Vladimir ;
Tincani, Angela ;
Troldborg, Anne ;
van Vollenhoven, Ronald ;
Wenzel, Joerg ;
Bertsias, George ;
Boumpas, Dimitrios T. .
ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 (06) :736-745
[4]   A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus [J].
Furie, Richard ;
Petri, Michelle ;
Zamani, Omid ;
Cervera, Ricard ;
Wallace, Daniel J. ;
Tegzova, Dana ;
Sanchez-Guerrero, Jorge ;
Schwarting, Andreas ;
Merrill, Joan T. ;
Chatham, W. Winn ;
Stohl, William ;
Ginzler, Ellen M. ;
Hough, Douglas R. ;
Zhong, Z. John ;
Freimuth, William ;
van Vollenhoven, Ronald F. .
ARTHRITIS AND RHEUMATISM, 2011, 63 (12) :3918-3930
[5]   Comorbidities in alopecia areata: A systematic review and meta-analysis [J].
Lee, Solam ;
Lee, Hanil ;
Lee, Chung Hyeok ;
Lee, Won-Soo .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2019, 80 (02) :466-+
[6]   Alopecia areata [J].
Pratt, C. Herbert ;
King, Lloyd E., Jr. ;
Messenger, Andrew G. ;
Christiano, Angela M. ;
Sundberg, John P. .
NATURE REVIEWS DISEASE PRIMERS, 2017, 3
[7]   Belimumab restores Treg/Th17 balance in patients with refractory systemic lupus erythematosus [J].
Prete, M. ;
Leone, P. ;
Frassanito, M. A. ;
Desantis, V. ;
Marasco, C. ;
Cicco, S. ;
Dammacco, F. ;
Vacca, A. ;
Racanelli, V. .
LUPUS, 2018, 27 (12) :1926-1935
[8]   Association Between Changes in BLyS Levels and the Composition of B and T Cell Compartments in Patients With Refractory Systemic Lupus Erythematosus Treated With Belimumab [J].
Regola, Francesca ;
Piantoni, Silvia ;
Lowin, Torsten ;
Archetti, Silvia ;
Reggia, Rossella ;
Kumar, Rajesh ;
Franceschini, Franco ;
Airo, Paolo ;
Tincani, Angela ;
Andreoli, Laura ;
Pongratz, Georg .
FRONTIERS IN PHARMACOLOGY, 2019, 10
[9]   Follicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets? [J].
Sawaf, Matthieu ;
Dumortier, Helene ;
Monneaux, Fanny .
JOURNAL OF IMMUNOLOGY RESEARCH, 2016, 2016
[10]   INCIDENCE OF ALOPECIA-AREATA IN LUPUS-ERYTHEMATOSUS [J].
WERTH, VP ;
WHITE, WL ;
SANCHEZ, MR ;
FRANKS, AG .
ARCHIVES OF DERMATOLOGY, 1992, 128 (03) :368-371