Visible light-induced singlet oxygen-mediated intracellular disassembly of polymeric micelles co-loaded with a photosensitizer and an anticancer drug for enhanced photodynamic therapy

被引：102
作者：
Saravanakumar, Gurusamy
Lee, Junseok
Kim, Jihoon
Kim, Won Jong [1 ]
机构：
[1] Pohang Univ Sci & Technol, Ctr Self Assembly & Complex, Inst Basic Sci, Pohang 790784, South Korea
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 49期
关键词：
DELIVERY; CANCER;
D O I：
10.1039/c5cc01937k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.
引用
收藏
页码：9995 / 9998
页数：4
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