The management of chronic peripheral neuropathic pain conditions with conventional treatments is still limited. In this present study, we aimed to determine the anti-neuropathic actions of pulsed magnetic field (PMF) treatments as a therapeutic. Effects of daily PMF treatments for 4 weeks were investigated by examining pain behaviors, hyperalgesia and allodynia, electrophysiological parameters, amplitude of compound action potential (CAP) and sciatic nerve conduction velocity (SNCV) and histopathological changes in rats with chronic constriction injury (CCI). Peripheral and central pro-inflammatory cytokines (TNF alpha, IL-113 and IL-17), chemokines (CCL3 and CXCL1) and angiogenic factors (VEGF and bFGF) in sciatic nerves and spinal cord tissues were also measured for determining the possible molecular action mechanisms of PMF treatment. Hyperalgesia and allodynia were observed at the first week and lasted for 4 weeks after CCI. PMF treatments caused timedependent anti-hyperalgesic and anti-allodynic effects. PMF treatment alleviated the histopathological consequences of CCI on sciatic nerve and significantly improved the amplitude of the CAP and SNCV. PMF treatment inhibited the pro-inflammatory molecules and promoted the anti-inflammatory cytokines in neural tissues. PMF treatment also suppressed the VEGF levels and enhanced the bFGF levels in both neural tissues. The results of the present study suggested that daily PMF treatment may have neuroprotective and anti-neuropathic pain actions in rats with CCI-induced neuropathy due to its modulating effects on neuro-inflammatory and neuro-angiogenic mediators in central and peripheral neural tissues.
机构:
Merck Res Labs, Dept Immunol, Rahway, NJ 07065 USAMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Abbadie, Catherine
Bhangoo, Sonia
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Northwestern Univ, Maywood, IL USAMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Bhangoo, Sonia
De Koninck, Yves
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Univ Laval Robert Giffard, Ctr Rech, Unite Neurobiol Cellulaire, Quebec City, PQ G1J 2G3, CanadaMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
De Koninck, Yves
Malcangio, Marzia
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Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, EnglandMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Malcangio, Marzia
Melik-Parsadaniantz, Stephane
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UPMC, Hop St Antoine, INSERM, Unite Mixte 732, F-75571 Paris, France
UPMC, Fac Med Pitie Salpetriere, INSERM, Unite Mixte 713, Paris, FranceMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Melik-Parsadaniantz, Stephane
White, Fletcher A.
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Loyola Univ, Maywood, IL 60153 USAMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
机构:
Seacroft Hosp, SpR Palliat Med, Chron Pain Team, Leeds LS14 6UH, W Yorkshire, EnglandSeacroft Hosp, SpR Palliat Med, Chron Pain Team, Leeds LS14 6UH, W Yorkshire, England
Callin, Sarah
Bennett, Michael I.
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机构:
St Gemmas Hospice, Clin Teaching & Res Unit, Palliat Med, Leeds LS17 6QD, W Yorkshire, England
Univ Lancaster, Inst Hlth Res, Palliat Med, Int Observ End Life Care, Bowland Tower East, Lancaster LA1 4YT, EnglandSeacroft Hosp, SpR Palliat Med, Chron Pain Team, Leeds LS14 6UH, W Yorkshire, England
机构:
Merck Res Labs, Dept Immunol, Rahway, NJ 07065 USAMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Abbadie, Catherine
Bhangoo, Sonia
论文数: 0引用数: 0
h-index: 0
机构:
Northwestern Univ, Maywood, IL USAMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Bhangoo, Sonia
De Koninck, Yves
论文数: 0引用数: 0
h-index: 0
机构:
Univ Laval Robert Giffard, Ctr Rech, Unite Neurobiol Cellulaire, Quebec City, PQ G1J 2G3, CanadaMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
De Koninck, Yves
Malcangio, Marzia
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Wolfson Ctr Age Related Dis, London SE1 1UL, EnglandMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Malcangio, Marzia
Melik-Parsadaniantz, Stephane
论文数: 0引用数: 0
h-index: 0
机构:
UPMC, Hop St Antoine, INSERM, Unite Mixte 732, F-75571 Paris, France
UPMC, Fac Med Pitie Salpetriere, INSERM, Unite Mixte 713, Paris, FranceMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
Melik-Parsadaniantz, Stephane
White, Fletcher A.
论文数: 0引用数: 0
h-index: 0
机构:
Loyola Univ, Maywood, IL 60153 USAMerck Res Labs, Dept Immunol, Rahway, NJ 07065 USA
机构:
Seacroft Hosp, SpR Palliat Med, Chron Pain Team, Leeds LS14 6UH, W Yorkshire, EnglandSeacroft Hosp, SpR Palliat Med, Chron Pain Team, Leeds LS14 6UH, W Yorkshire, England
Callin, Sarah
Bennett, Michael I.
论文数: 0引用数: 0
h-index: 0
机构:
St Gemmas Hospice, Clin Teaching & Res Unit, Palliat Med, Leeds LS17 6QD, W Yorkshire, England
Univ Lancaster, Inst Hlth Res, Palliat Med, Int Observ End Life Care, Bowland Tower East, Lancaster LA1 4YT, EnglandSeacroft Hosp, SpR Palliat Med, Chron Pain Team, Leeds LS14 6UH, W Yorkshire, England