Extracellular Environment-Controlled Angiogenesis, and Potential Application for Peripheral Nerve Regeneration

被引：31

作者：

Saio, Shingo ^{[1
]}

Konishi, Kanna ^{[1
]}

Hohjoh, Hirofumi ^{[2
]}

Tamura, Yuki ^{[1
]}

Masutani, Teruaki ^{[3
,4
]}

Iddamalgoda, Arunasiri ^{[3
]}

Ichihashi, Masamitsu ^{[1
]}

Hasegawa, Hiroshi ^{[2
]}

Mizutani, Ken-ichi ^{[1
]}

机构：

[1] Kobe Gakuin Univ, Grad Sch Pharmaceut Sci, Lab Stem Cell Biol, Chuo Ku, 1-1-3 Minatojima, Kobe, Hyogo 6508586, Japan

[2] Kobe Pharmaceut Univ, Lab Hyg Sci, Higashinada Ku, 4-19-1 Motoyamakitamachi, Kobe, Hyogo 6588558, Japan

[3] Ichimaru Pharcos Co Ltd, Res & Dev Dept, 318-1 Asagi, Motosu 5010475, Japan

[4] Gifu Univ, Med Educ Dev Ctr, Sch Med, 1-1 Yanagido, Gifu 5011194, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 20期

关键词：

angiogenesis; extracellular matrix; proteoglycan; peripheral nerve regeneration; ENDOTHELIAL GROWTH-FACTOR; AXONAL OUTGROWTH; HEPARAN-SULFATE; SCHWANN-CELLS; PERLECAN; MATRIX; PROTEOGLYCAN; MUSCLE; PROLIFERATION; AGRIN;

D O I：

10.3390/ijms222011169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial cells acquire different phenotypes to establish functional vascular networks. Vascular endothelial growth factor (VEGF) signaling induces endothelial proliferation, migration, and survival to regulate vascular development, which leads to the construction of a vascular plexuses with a regular morphology. The spatiotemporal localization of angiogenic factors and the extracellular matrix play fundamental roles in ensuring the proper regulation of angiogenesis. This review article highlights how and what kinds of extracellular environmental molecules regulate angiogenesis. Close interactions between the vascular and neural systems involve shared molecular mechanisms to coordinate developmental and regenerative processes. This review article focuses on current knowledge about the roles of angiogenesis in peripheral nerve regeneration and the latest therapeutic strategies for the treatment of peripheral nerve injury.</p>

引用

页数：10

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