Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study

被引：112

作者：

Lee, Seung Won ^{[1
]}

Lee, Jinhee ^{[2
]}

Moon, Sung Yong ^{[1
]}

Jin, Hyun Young ^{[1
]}

Yang, Jee Myung ^{[3
]}

Ogino, Shuji ^{[4
,5
,6
]}

Song, Mingyang ^{[4
]}

Hong, Sung Hwi ^{[7
]}

Abou Ghayda, Ramy ^{[8
]}

Kronbichler, Andreas ^{[9
]}

Koyanagi, Ai ^{[10
,11
]}

Jacob, Louis ^{[10
,12
,13
]}

Dragioti, Elena ^{[14
,15
]}

Smith, Lee ^{[16
]}

Giovannucci, Edward ^{[4
,6
,17
,18
]}

Lee, I-Min ^{[4
,19
]}

Lee, Dong Hoon ^{[18
]}

Lee, Keum Hwa ^{[20
]}

Shin, Youn Ho ^{[21
]}

Kim, So Young ^{[22
]}

Kim, Min Seo ^{[23
]}

Won, Hong-Hee ^{[23
]}

Ekelund, Ulf ^{[24
,25
]}

Shin, Jae Il ^{[20
]}

Yon, Dong Keon ^{[26
]}

机构：

[1] Sejong Univ, Coll Software Convergence, Dept Data Sci, Seoul 03722, South Korea

[2] Yonsei Univ, Wonju Coll Med, Dept Psychiat, Wonju, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Ophthalmol, Seoul, South Korea

[4] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[5] Brigham & Womens Hosp, Dept Pathol, Program MPE Mol Pathol Epidemiol, 75 Francis St, Boston, MA 02115 USA

[6] Harvard Med Sch, Boston, MA 02115 USA

[7] Yonsei Univ, Coll Med, Seoul, South Korea

[8] Case Western Reserve Univ, Univ Hosp, Urol Inst, Cleveland, OH 44106 USA

[9] Univ Cambridge, Dept Med, Cambridge, England

[10] Parc Sanitari St Joan de Deu, CIBERSAM, Res & Dev Unit, Barcelona, Spain

[11] Catalan Inst Res & Adv Studies ICREA, Pg Lluis Co, Barcelona, Spain

[12] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

[13] Univ Versailles St Quentin En Yvelines, Fac Med, Montigny Le Bretonneux, France

[14] Linkoping Univ, Pain & Rehabil Ctr, Linkoping, Sweden

[15] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden

[16] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Chelmsford, Essex, England

[17] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[18] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[19] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA

[20] Yonsei Univ, Coll Med, Dept Pediat, Seoul 03722, South Korea

[21] CHA Univ, Sch Med, CHA Gangnam Med Ctr, Dept Pediat, Seoul, South Korea

[22] CHA Univ, Sch Med, CHA Bundang Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam, South Korea

[23] Sungkyunkwan Univ, Samsung Med Ctr, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea

[24] Norwegian Sch Sports Sci, Dept Sports Med, Oslo, Norway

[25] Norwegian Inst Publ Hlth, Dept Chron Dis & Ageing, Oslo, Norway

[26] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Pediat, Seoul 08826, South Korea

来源：

BRITISH JOURNAL OF SPORTS MEDICINE | 2022年 / 56卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

COVID-19; physical activity;

D O I：

10.1136/bjsports-2021-104203

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

Purpose To determine the potential associations between physical activity and risk of SARS-CoV-2 infection, severe illness from COVID-19 and COVID-19 related death using a nationwide cohort from South Korea. Methods Data regarding 212 768 Korean adults (age >= 20 years), who tested for SARS-CoV-2, from 1 January 2020 to 30 May 2020, were obtained from the National Health Insurance Service of South Korea and further linked with the national general health examination from 1 January 2018 to 31 December 2019 to assess physical activity levels. SARS-CoV-2 positivity, severe COVID-19 illness and COVID-19 related death were the main outcomes. The observation period was between 1 January 2020 and 31 July 2020. Results Out of 76 395 participants who completed the general health examination and were tested for SARS-CoV-2, 2295 (3.0%) were positive for SARS-CoV-2, 446 (0.58%) had severe illness from COVID-19 and 45 (0.059%) died from COVID-19. Adults who engaged in both aerobic and muscle strengthening activities according to the 2018 physical activity guidelines had a lower risk of SARS-CoV-2 infection (2.6% vs 3.1%; adjusted relative risk (aRR), 0.85; 95% CI 0.72 to 0.96), severe COVID-19 illness (0.35% vs 0.66%; aRR 0.42; 95% CI 0.19 to 0.91) and COVID-19 related death (0.02% vs 0.08%; aRR 0.24; 95% CI 0.05 to 0.99) than those who engaged in insufficient aerobic and muscle strengthening activities. Furthermore, the recommended range of metabolic equivalent task (MET; 500-1000 MET min/week) was associated with the maximum beneficial effect size for reduced risk of SARS-CoV-2 infection (aRR 0.78; 95% CI 0.66 to 0.92), severe COVID-19 illness (aRR 0.62; 95% CI 0.43 to 0.90) and COVID-19 related death (aRR 0.17; 95% CI 0.07 to 0.98). Similar patterns of association were observed in different sensitivity analyses. Conclusion Adults who engaged in the recommended levels of physical activity were associated with a decreased likelihood of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related death. Our findings suggest that engaging in physical activity has substantial public health value and demonstrates potential benefits to combat COVID-19.

引用

页码：901 / +

页数：13

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