New efficient synthesis of multisubstituted benzimidazoles and quinoxalin-2(1H)-ones by a Ugi 4CC/aza-Wittig sequence starting from, aromatic amine precursors

被引：23

作者：

Yan, Yan-Mei ^{[1
]}

Gao, Yun ^{[1
]}

Ding, Ming-Wu ^{[1
]}

机构：

[1] Cent China Normal Univ, Minist Educ, Key Lab Pesticide & Chem Biol, Wuhan 430079, Peoples R China

来源：

TETRAHEDRON | 2016年 / 72卷 / 35期

基金：

中国国家自然科学基金;

关键词：

Ugi reaction; aza-Wittig reaction; C-H activation; Benzimidazole Quinoxalin-2(1H)-one; AZA-WITTIG REACTION; ONE-POT SYNTHESIS; QUINOXALINONE DERIVATIVES; POTENTIAL ANTICANCER; INHIBITORS; DESIGN; ANTIOXIDANT; CYCLIZATION; DISCOVERY; CHEMISTRY;

D O I：

10.1016/j.tet.2016.07.048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient preparation of multisubstituted benzimidazoles and quinoxalin-2(1H)-ones by Ugi 4CC/aza-Wittig sequence was developed. The 2-azidobenzenamines, obtained from C-H activation of aromatic amine precursors, reacted with aldehydes, acids, and isocyanides to produce Ugi products, which were transformed to the benzimidazoles or quinoxalin-2(1H)-ones in moderate to good yields in further reaction with triphenylphosphine. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：5548 / 5557

页数：10

共 33 条

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