Ubiquitination of MDM2 modulated by Epstein-Barr virus encoded latent membrane protein 1

被引：17

作者：

Li, Lili ^{[1
]}

Li, Zijian ^{[1
]}

Zhou, Shanghui ^{[1
]}

Xiao, Lanbo ^{[1
]}

Guo, Lili ^{[1
]}

Tao, Yongguang ^{[1
]}

Tang, Min ^{[1
]}

Shi, Ying ^{[1
]}

Li, Wei ^{[1
]}

Yi, Wei ^{[1
]}

Cao, Ya ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Sch Med, Canc Res Inst, Changsha, Peoples R China

来源：

VIRUS RESEARCH | 2007年 / 130卷 / 1-2期

关键词：

MDM2; Epstein-Barr virus; latent membrane protein 1; ubiquitination;

D O I：

10.1016/j.virusres.2007.05.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Epstein-Barr virus encoded latent membrane protein 1 (LMP1), an oncogenic protein, plays an important role in the carcinogenesis of nasopharyngeal carcinoma. The MDM2 gene is a cellular pro-oncogene that is abnormally up-regulated in human tumors. MDM2 is overexpressed in nasopharyngeal carcinoma, which is associated with the presence of EBV and cervical lymph node metastasis. Because MDM2 is capable of self-ubiquitination, and the ubiquitin proteasome pathway-dependent degradation is an important mechanism for regulating MDM2 levels in cells. Here we show that LMP1 augment MDM2 protein expression in dose-dependent level, and also lead to a drastic accumulation of ubiquitinated MDM2,species, this effect is associated with the stability of MDM2 modulated by LMP1. This is the first time to explain LMP1-regulated MDM2 through a post-ubiquitination mechanism. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：275 / 280

页数：6

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