Comparison of various bioreactors on growth and artemisinin biosynthesis of Artemisia annua L. shoot cultures

被引：21
|
作者：
Liu, CZ [1 ]
Guo, C [1 ]
Wang, YC [1 ]
Ouyang, F [1 ]
机构：
[1] Chinese Acad Sci, Inst Proc Engn, State Key Biochem Engn, Beijing 100080, Peoples R China
来源：
PROCESS BIOCHEMISTRY | 2003年 / 39卷 / 01期
关键词：
Artemisia annua L; shoot culture; growth; artemisinin biosynthesis; bioreactor; plant-specific valuable metabolite production;
D O I：
10.1016/S0032-9592(02)00294-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Shoot cultures of Artemisia annua L. were cultivated in three different bioreactors: a modified airlift bioreactor, a multi-plate radius-flow bioreactor and an ultrasonic nutrient mist bioreactor. The shoots cultivated in the multi-plate radius-flow bioreactor and nutrient mist bioreactor showed excellent growth; however; hyperhydrated shoots were observed in the totally immersion cultivation in the modified airlift bioreactor. The dry weight increase (45 times) of shoot cultures in the mist bioreactor was higher than those (29 times and 36 times) in both the modified airlift bioreactor and the multi-plate radius-flow bioreactor. Furthermore, artemisinin production of shoot cultures in the nutrient mist bioreactor was 1.4- and 3.3-fold higher than those in both the multi-plate radius-flow bioreactor and the modified airlift bioreactor, respectively. The mist bioreactor was found to be advantageous for A. annua L. shoot cultures. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：45 / 49
页数：5
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