Inhibitory effect of Hesperidin on tumour initiation and promotion in mouse skin

被引：57
|
作者：
Berkarda, B
Koyuncu, H
Soybir, G
Baykut, F
机构：
[1] Univ Istanbul, Cerrahpasa Med Sch, Dept Haematol, Istanbul, Turkey
[2] Univ Istanbul, Inst Oncol, Istanbul, Turkey
[3] Taksim State Hosp, Dept Surg, Istanbul, Turkey
[4] Univ Istanbul, Cerrahpasa Med Sch, Dept Biomed Engn, Istanbul, Turkey
来源：
RESEARCH IN EXPERIMENTAL MEDICINE | 1998年 / 198卷 / 02期
关键词：
hesperidin; skin tumorigenesis; mice;
D O I：
10.1007/s004330050093
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A flavonoid, Hesperidin was evaluated for its ability to inhibit tumour initiation by a polycyclic aromatic hydrocarbon and tumour promotion by a phorbol ester in the skin of CD-1 mice. Subcutaneous application of Hesperidin did not inhibit 7,12-dimethylbenz(a)anthracene-induced tumour initiation but did inhibit 12-O-tetradecanoyl-13-phorbol acetate-induced tumour promotion. Results provide evidence for a potential chemopreventive activity of Hesperidin.
引用
收藏
页码：93 / 99
页数：7
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