Immunomodulatory Action of Monosulfated Triterpene Glycosides from the Sea Cucumber Cucumaria okhotensis: Stimulation of Activity of Mouse Peritoneal Macrophages

被引：1
作者：
Aminin, Dmitry L. [1 ]
Silchenko, Alexandra S. [1 ]
Avilov, Sergey A. [1 ]
Stepanov, Vadim G. [2 ]
Kalinin, Vladimir I. [1 ]
机构：
[1] Russian Acad Sci, Pacific Inst Bioorgan Chem, Vladivostok 690022, Russia
[2] Pacific Inst Geog, Kamchatka Dept, Petropavlovsk Kamchatski 683000, Russia
来源：
NATURAL PRODUCT COMMUNICATIONS | 2010年 / 5卷 / 12期
关键词：
triterpene glycosides; Cucumaria okhotensis; macrophages; ROS formation; spreading; lysosomal activity; FRONDOSIDE-A; ACTIVATION;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six monosulfated triterpene glycosides, frondoside A(1) (1), okhotoside B-1 (2), okhotoside A(1)-1 (3), frondoside A (4), okhotoside A(2)-1 (5) and cucumarioside A(2)-5 (6), isolated from Cucumaria okhotensis Levin et Stepanov, stimulate spreading and lysosomal activity of mouse macrophages and ROS-fonnation in the macrophages. The highest macrophage spreading and stimulation of their lysosomal activity was induced by glycosides 1, 4 and 6. All glycosides similarly stimulate ROS formation in macrophages, but glycoside 2 caused minimal stimulation.
引用
收藏
页码：1877 / 1880
页数：4
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