Suppressive effects of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine on the Toll-like receptor signaling pathways

被引：3

作者：

Ahn, Sang-Il ^{[1
]}

Lim, Se Jin ^{[2
]}

Gu, Gyo-Jeong ^{[1
]}

Hong, Chae-Yeon ^{[2
]}

Kim, Ji-Soo ^{[1
]}

Jeong, Hyun Jung ^{[3
]}

Koh, Kwang Oh ^{[3
]}

Mang, Joo Yang ^{[3
]}

Kim, Dae Young ^{[3
]}

Youn, Hyung-Sun ^{[1
,2
]}

机构：

[1] Soonchunhyang Univ, Coll Med Sci, Dept Med Sci, Asan 336745, Chungnam, South Korea

[2] Soonchunhyang Univ, Coll Med Sci, Dept Biomed Lab Sci, Asan 336745, Chungnam, South Korea

[3] Soonchunhyang Univ, Coll Nat Sci, Dept Chem, Asan 336745, Chungnam, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2015年 / 24卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Toll-like receptor; NF-kappa B; IRF3; Cyclooxygenase-2; Inducible nitric oxide synthase; NF-KAPPA-B; IFN-REGULATORY FACTOR-3; TANK-BINDING KINASE-1; SESQUITERPENE LACTONES; GENE-EXPRESSION; VIRAL-INFECTION; IKK-EPSILON; ACTIVATION; LIPOPOLYSACCHARIDE; TRANSCRIPTION;

D O I：

10.1016/j.intimp.2014.10.033

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

When various pathogens invade a host, toll-like receptors (TLRs) play a significant role in recognizing the pathogen-associated molecular patterns carried by the pathogens to induce innate immune reaction, followed by acquired immunity reaction. TLRs have two downstream signaling pathways, the myeloid differential factor 88 (MyD88)-dependent and toll-interleukin-1 receptor domain-containing adapter inducing interferon-beta (TRIF)-dependent pathways. To evaluate the therapeutic potential of 1-[4-fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine (FPP), previously synthesized in our laboratory, its effect on signal transduction via the TLR signaling pathways was examined. FPP inhibited the activation of nuclear factor-kappa B (NF-kappa B) and interferon regulatory factor 3 (IRF3) induced by TLR agonists, as well as inhibited the expression of cydooxygenase-2, inducible nitric oxide synthase, and interferon inducible protein-10. FPP also inhibited the activation of NF-kappa B and IRF3 when induced by the overexpression of downstream signaling components of the TLRs. As a result, FPP has potential to become a new therapeutic drug for many inflammatory diseases. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：36 / 41

页数：6

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