Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetic Rats

被引：76
作者：
Ahmed, Mohammed Fazil [1 ,2 ,3 ]
Kazim, Syed Mohammed [1 ,2 ,3 ]
Ghori, Syed Safiullah [1 ,2 ,3 ]
Mehjabeen, Syeda Sughra [1 ,2 ,3 ]
Ahmed, Shaik Rasheed [1 ,2 ,3 ]
Ali, Shaik Mehboob [4 ]
Ibrahim, Mohammed [1 ,2 ,3 ]
机构：
[1] Nizam Inst Pharm, Dept Pharmacol & Biotechnol, Nalgonda 508284, Andhra Pradesh, India
[2] Deccan Coll Med Sci, Ctr Liver Res & Diagnost, Hyderabad 500058, Andhra Pradesh, India
[3] Allied Hosp Kanchanbagh, Hyderabad 500058, Andhra Pradesh, India
[4] Moana Marine Biotech Ltd, Dept Microbiol, Vishakapatnam 530027, Andhra Pradesh, India
来源：
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2010年 / 2010卷
关键词：
ENZYMATIC DETERMINATION; CATHARANTHUS-ROSEUS; REGENERATION; CHOLESTEROL; METABOLISM; LEAF;
D O I：
10.1155/2010/841090
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The present study was carried out to evaluate the antidiabetic activity of Vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. The methanolic whole plant extract at high dose (500 mg/kg) exhibited significant anti-hyperglycemic activity than whole plant extract at low dose (300 mg/kg) in diabetic rats. The methanolic extracts also showed improvement in parameters like body weight and lipid profile as well as regeneration of beta-cells of pancreas in diabetic rats. Histopathological studies reinforce the healing of pancreas, by methanolic Vinca rosea extracts, as a possible mechanism of their antidiabetic activity.
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页数：6
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