A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
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作者:
Kampman, Kyle M.
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机构:
Univ Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USAUniv Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
Kampman, Kyle M.
[1
]
Dackis, Charles
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机构:Univ Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
Dackis, Charles
Pettinati, Helen M.
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机构:Univ Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
Pettinati, Helen M.
Lynch, Kevin G.
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机构:Univ Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
Lynch, Kevin G.
Sparkman, Thorne
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Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USAUniv Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
Sparkman, Thorne
[2
]
O'Brien, Charles P.
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机构:
Res Educ & Clin Ctr, VISN 4 Mental Illness, Dept Vet Affairs, Philadelphia, PA 19104 USAUniv Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
O'Brien, Charles P.
[3
]
机构:
[1] Univ Penn, Treatment Res Ctr, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
[3] Res Educ & Clin Ctr, VISN 4 Mental Illness, Dept Vet Affairs, Philadelphia, PA 19104 USA
Background: Acamprosate is a medication shown to be effective for the treatment of alcohol dependence. Although the exact mechanism of action of acamprosate is unknown, evidence suggests that it decreases excitatory amino acid activity by post-synaptic inhibition of the NMDA subtype of glutamate receptors. It is possible that the activity of acamprosate via modulating glutamatergic activity could also reduce craving for cocaine and impact abstinence in cocaine dependence. Therefore, we conducted a double-blind placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence. Methods: Sixty male and female cocaine dependent patients were included in a nine week double-blind, placebo-controlled trial. After a one-week baseline, patients were randomized to receive acamprosate 666 mg three times daily or identical placebo tablets for eight weeks. The primary outcome measure was cocaine use as determined by twice weekly urine drug screens. Results: Thirty-six patients (60%) completed the trial, with no significant between-group difference in treatment retention. Percent cocaine positive urine drug screens did not differ between the two groups. Acamprosate was no better than placebo in reducing cocaine craving, reducing cocaine withdrawal symptoms, or improving measures of drug use severity from the Addiction Severity Index. Adverse events in this trial were generally mild and were evenly distributed between the two groups. Discussion: Acamprosate was well tolerated but was no more efficacious than placebo in promoting abstinence from cocaine in cocaine dependent patients. Acamprosate does not appear to be a promising medication for the treatment of cocaine dependence. (C) 2010 Elsevier Ltd. All rights reserved.
机构:
Kurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Pasdaran Blvd, Sanandaj, IranKurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Pasdaran Blvd, Sanandaj, Iran
Rezaei, Farzin
Ghaderi, Ebrahim
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Kurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Pasdaran Blvd, Sanandaj, IranKurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Pasdaran Blvd, Sanandaj, Iran
Ghaderi, Ebrahim
Mardani, Roya
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Kurdistan Univ Med Sci, Student Res Comm, Pasdaran Blvd, Sanandaj, IranKurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Pasdaran Blvd, Sanandaj, Iran
Mardani, Roya
Hamidi, Seiran
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Kurdistan Univ Med Sci, Ghods Hosp, Pasdaran Blvd, Sanandaj, IranKurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Pasdaran Blvd, Sanandaj, Iran
Hamidi, Seiran
Hassanzadeh, Kambiz
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Kurdistan Univ Med Sci, Cellular & Mol Res Ctr, Pasdaran Blvd, Sanandaj, Iran
Kurdistan Univ Med Sci, Fac Med, Dept Physiol & Pharmacol, Pasdaran Blvd, Sanandaj, IranKurdistan Univ Med Sci, Social Determinants Hlth Res Ctr, Pasdaran Blvd, Sanandaj, Iran
机构:
New York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USANew York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Levin, Frances R.
Mariani, John J.
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New York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USANew York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Mariani, John J.
Brooks, Daniel J.
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New York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USANew York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Brooks, Daniel J.
Pavlicova, Martina
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Columbia Univ, Dept Biostat, New York, NY 10032 USANew York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Pavlicova, Martina
Cheng, Wendy
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New York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USANew York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Cheng, Wendy
Nunes, Edward V.
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New York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY 10032 USANew York State Psychiat Inst & Hosp, Div Subst Abuse, New York, NY 10032 USA
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Integrated Substance Abuse Programs, Los Angeles, CA 90025 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Heinzerling, Keith G.
Swanson, Aimee-Noelle
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Swanson, Aimee-Noelle
Kim, Soeun
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Biostat, Los Angeles, CA 90024 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Kim, Soeun
Cederblom, Lisa
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Cederblom, Lisa
Moe, Ardis
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90024 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Moe, Ardis
Ling, Walter
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Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Integrated Substance Abuse Programs, Los Angeles, CA 90025 USA
Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Ling, Walter
Shoptaw, Steven
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机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Integrated Substance Abuse Programs, Los Angeles, CA 90025 USA
Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USAUniv Calif Los Angeles, David Geffen Sch Med, Dept Family Med, Los Angeles, CA 90095 USA
机构:
San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Univ Calif San Francisco, San Francisco, CA 94143 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Coffin, Phillip Oliver
Santos, Glenn-Milo
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San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Univ Calif San Francisco, San Francisco, CA 94143 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Santos, Glenn-Milo
Das, Moupali
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San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Univ Calif San Francisco, San Francisco, CA 94143 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Das, Moupali
Santos, Deirdre M.
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San Francisco Dept Publ Hlth, San Francisco, CA 94102 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Santos, Deirdre M.
Huffaker, Shannon
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San Francisco Dept Publ Hlth, San Francisco, CA 94102 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Huffaker, Shannon
Matheson, Tim
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San Francisco Dept Publ Hlth, San Francisco, CA 94102 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Matheson, Tim
Gasper, James
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San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Univ Calif San Francisco, San Francisco, CA 94143 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Gasper, James
Vittinghoff, Eric
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Univ Calif San Francisco, San Francisco, CA 94143 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Vittinghoff, Eric
Colfax, Grant N.
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San Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
Univ Calif San Francisco, San Francisco, CA 94143 USASan Francisco Dept Publ Hlth, San Francisco, CA 94102 USA
机构:
Columbia Univ, New York State Psychiat Inst, New York, NY 10027 USA
Columbia Univ, Dept Psychiat, New York, NY 10027 USAUniv Minnesota, Dept Psychiat, Minneapolis, MN 55454 USA
机构:
Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA
Vet Affairs Connecticut Healthcare Syst, West Haven, CT USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Martell, Bridget A.
Orson, Frank M.
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Michael E DeBakey VA Med Ctr, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Orson, Frank M.
Poling, James
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Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
Vet Affairs Connecticut Healthcare Syst, West Haven, CT USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Poling, James
Mitchell, Ellen
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Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
Vet Affairs Connecticut Healthcare Syst, West Haven, CT USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Mitchell, Ellen
Rossen, Roger D.
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Michael E DeBakey VA Med Ctr, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Rossen, Roger D.
Gardner, Tracie
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机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Med, Houston, TX 77030 USA
Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA
Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Gardner, Tracie
Kosten, Thomas R.
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机构:
Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Dept Med, Houston, TX 77030 USA
Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA
Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Houston, TX 77030 USA