Supercritical focusing coherent anti-Stokes Raman scattering microscopy for high-resolution vibrational imaging

被引：14

作者：

Gong, Li ^{[1
]}

Lin, Jian ^{[1
]}

Hao, Chenglong ^{[2
]}

Zheng, Wei ^{[1
,3
]}

Wu, Steve Qing Yang ^{[4
]}

Teng, Jinghua ^{[4
]}

Qiu, Cheng-wei ^{[2
]}

Huang, Zhiwei ^{[1
]}

机构：

[1] Natl Univ Singapore, Opt Bioimaging Lab, Dept Biomed Engn, Fac Engn, Singapore 117576, Singapore

[2] Natl Univ Singapore, Dept Elect & Comp Engn, Fac Engn, Singapore 117583, Singapore

[3] Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore 119260, Singapore

[4] ASTAR, Inst Mat Res & Engn, Singapore 138634, Singapore

来源：

OPTICS LETTERS | 2018年 / 43卷 / 22期

基金：

英国医学研究理事会;

关键词：

CARS MICROSCOPY; DIFFRACTION; LIGHT;

D O I：

10.1364/OL.43.005615

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We report the development of, to the best of our knowledge, a novel supercritical focusing coherent anti-Stokes Raman scattering (SCF-CARS) microscopy for high-resolution vibrational imaging. Two optimized phase patterns with a combination of concentric rings with an alternative 0 and pi phase are generated by using a spatial light modulator and applied to the pump beam for minimizing its focal spot size. One of the phase patterns is for both the lateral and axial resolution enhancement, and the other can further improve the lateral resolution, but it sacrifices the axial resolution to some extent. We demonstrate this high-resolution SCF-CARS microscopy technique by imaging the polymethyl methacrylate (PMMA) nano-cylinder on a microscope slide and glass-air interface, as well as biomedical samples, for example, tooth. (C) 2018 Optical Society of America

引用

页码：5615 / 5618

页数：4

共 21 条

[1] Quantitative assessment of spinal cord injury using circularly polarized coherent anti-Stokes Raman scattering microscopy [J].

Bae, Kideog ;

Zheng, Wei ;

Huang, Zhiwei .

APPLIED PHYSICS LETTERS, 2017, 111 (06)

[2] Improvement of Spatial Resolution for Nonlinear Raman Microscopy by Spatial Light Modulation [J].

Banno, Motohiro ;

Onda, Konosuke ;

Yui, Hiroharu .

ANALYTICAL SCIENCES, 2017, 33 (01) :69-74

[3] Spatially dependent Rabi oscillations: An approach to sub-diffraction-limited coherent anti-Stokes Raman-scattering microscopy [J].

Beeker, Willem P. ;

Lee, Chris J. ;

Boller, Klaus-Jochen ;

Gross, Petra ;

Cleff, Carsten ;

Fallnich, Carsten ;

Offerhaus, Herman L. ;

Herek, Jennifer L. .

PHYSICAL REVIEW A, 2010, 81 (01)

[4] A route to sub-diffraction-limited CARS Microscopy [J].

Beeker, Willem P. ;

Gross, Petra ;

Lee, Chris J. ;

Cleff, Carsten ;

Offerhaus, Herman L. ;

Fallnich, Carsten ;

Herek, Jennifer L. ;

Boller, Klaus-Jochen .

OPTICS EXPRESS, 2009, 17 (25) :22632-22638

[5] Coherent anti-Stokes Raman scattering microscopy: Instrumentation, theory, and applications [J].

Cheng, JX ;

Xie, XS .

JOURNAL OF PHYSICAL CHEMISTRY B, 2004, 108 (03) :827-840

[6] Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy [J].

Cheng, JX ;

Volkmer, A ;

Xie, XS .

JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, 2002, 19 (06) :1363-1375

[7] Ground-state depletion for subdiffraction-limited spatial resolution in coherent anti-Stokes Raman scattering microscopy [J].

Cleff, Carsten ;

Gross, Petra ;

Fallnich, Carsten ;

Offerhaus, Herman L. ;

Herek, Jennifer L. ;

Kruse, Kai ;

Beeker, Willem P. ;

Lee, Chris J. ;

Boller, Klaus-Jochen .

PHYSICAL REVIEW A, 2012, 86 (02)

[8]

Edward T. F. R., 2013, J OPT, V15

[9] Triple-frequency symmetric subtraction scheme for nonresonant background suppression in coherent anti-Stokes Raman scattering (CARS) microscopy [J].

Fang, Chao ;

Lu, Fake ;

Zheng, Wei ;

Huang, Zhiwei .

OPTICS EXPRESS, 2010, 18 (15) :15714-15724

[10]

Fu Min H., 2007, J OPT A-PURE APPL OP, V9, pS285

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