Investigation of 1H nuclear magnetic resonance relaxometry to screen metabolic syndrome and diabetes

被引：2
作者：
Jiang, Xiaowen [1 ]
Chen, Yi [1 ]
Wang, Junnan [1 ]
Wu, Zhengxiu [1 ]
Wang, Donglei [2 ]
Qiu, Shanhu [2 ]
Ni, Zhonghua [1 ]
Sun, Zilin [2 ]
Yi, Hong [1 ]
Lu, Rongsheng [1 ,3 ]
机构：
[1] Southeast Univ, Jiangsu Key Lab Design & Mfg Micro Nano Biomed In, Nanjing 211189, Peoples R China
[2] Southeast Univ, Zhongda Hosp, Dept Endocrinol, Inst Diabet,Med Sch, Nanjing 211189, Peoples R China
[3] Southeast Univ, State Key Lab Bioelect, Nanjing 211189, Peoples R China
来源：
ANALYTICAL SCIENCES | 2022年 / 38卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Diabetes; Metabolic syndrome; H-1 NMR relaxometry; T-2 and T-1 relaxation time; TIME; HEMOGLOBIN; EXCHANGE; BLOOD;
D O I：
10.1007/s44211-022-00113-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The purpose of this study was to investigate and compare the abilities of H-1 nuclear magnetic resonance (NMR) transverse relaxation constant time (T-2) and longitudinal relaxation constant time (T-1) to screen people at the risk of diabetes and metabolic syndrome. Human blood samples were collected for NMR detection and biochemical examinations. Bivariate correlations, categorical analyses were performed to explore the relationship between NMR relaxation time and metabolic biomarkers. Results show that NMR relaxation time of human serum correlated well with some biomarkers associated with diabetes and metabolic syndrome. Statistically significant differences in NMR relaxation time between subjects with normal and poor metabolic health were observed. NMR relaxation time, especially T-2, can be used to screen people at risk of diabetes and metabolic syndrome.
引用
收藏
页码：899 / 905
页数：7
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