Investigation of 1H nuclear magnetic resonance relaxometry to screen metabolic syndrome and diabetes

被引：2
|
作者：
Jiang, Xiaowen [1 ]
Chen, Yi [1 ]
Wang, Junnan [1 ]
Wu, Zhengxiu [1 ]
Wang, Donglei [2 ]
Qiu, Shanhu [2 ]
Ni, Zhonghua [1 ]
Sun, Zilin [2 ]
Yi, Hong [1 ]
Lu, Rongsheng [1 ,3 ]
机构：
[1] Southeast Univ, Jiangsu Key Lab Design & Mfg Micro Nano Biomed In, Nanjing 211189, Peoples R China
[2] Southeast Univ, Zhongda Hosp, Dept Endocrinol, Inst Diabet,Med Sch, Nanjing 211189, Peoples R China
[3] Southeast Univ, State Key Lab Bioelect, Nanjing 211189, Peoples R China
来源：
ANALYTICAL SCIENCES | 2022年 / 38卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Diabetes; Metabolic syndrome; H-1 NMR relaxometry; T-2 and T-1 relaxation time; TIME; HEMOGLOBIN; EXCHANGE; BLOOD;
D O I：
10.1007/s44211-022-00113-7
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The purpose of this study was to investigate and compare the abilities of H-1 nuclear magnetic resonance (NMR) transverse relaxation constant time (T-2) and longitudinal relaxation constant time (T-1) to screen people at the risk of diabetes and metabolic syndrome. Human blood samples were collected for NMR detection and biochemical examinations. Bivariate correlations, categorical analyses were performed to explore the relationship between NMR relaxation time and metabolic biomarkers. Results show that NMR relaxation time of human serum correlated well with some biomarkers associated with diabetes and metabolic syndrome. Statistically significant differences in NMR relaxation time between subjects with normal and poor metabolic health were observed. NMR relaxation time, especially T-2, can be used to screen people at risk of diabetes and metabolic syndrome.
引用
收藏
页码：899 / 905
页数：7
相关论文
共 50 条
  • [21] Metabolic syndrome, type 1 diabetes mellitus and insulin resistance
    Jose Chillaron, Juan
    Goday, Albert
    Pedro-Botet, Juan
    MEDICINA CLINICA, 2008, 130 (12): : 466 - 471
  • [22] Myocardial Structural Remodeling and Tissue Composition by Cardiac Magnetic Resonance (CMR) in Relation to Metabolic Syndrome in Type 1 Diabetes: The DCCT/EDIC Study
    Turkbey, Evrim B.
    Backlund, Jye-Yu C.
    Cleary, Patricia A.
    Nacif, Marcelo S.
    Gai, Neville
    van der Geest, Rob J.
    Armstrong, Anderson
    Volpe, Gustavo J.
    Nazarian, Saman
    Lachin, John M.
    Lima, Joao A.
    Bluemke, David A.
    CIRCULATION, 2012, 126 (21)
  • [23] Depression is associated with the metabolic syndrome among patients with type 1 diabetes
    Ahola, Aila J.
    Thorn, Lena M.
    Saraheimo, Markku
    Forsblom, Carol
    Groop, Per-Henrik
    ANNALS OF MEDICINE, 2010, 42 (07) : 495 - 501
  • [24] ALCOHOL IN ADULTS WITH TYPE 1 DIABETES MELLITUS: IMPACT ON METABOLIC SYNDROME
    Alicia Beatriz, Garcia
    Alicia Beatriz, Garcia
    Lopez Gonzalez, Eva
    Houssay, Solange
    Milrad, Silviana
    Ruiz Morosini, Maria Lidia
    Luongo, Angela
    Varela, Maria Cristina
    Gonzalez, Claudia D.
    ANNALS OF NUTRITION AND METABOLISM, 2017, 71 : 1025 - 1025
  • [25] Two-dimensional low-field nuclear magnetic resonance approach for the detection of metabolic syndrome in human serum
    Wu, Yuchen
    Jiang, Xiaowen
    Chen, Yi
    Ni, Zhonghua
    Lu, Rongsheng
    SPECTROSCOPY LETTERS, 2024, 57 (10) : 647 - 657
  • [26] Glycoprotein Profile Measured by a 1H-Nuclear Magnetic Resonance Based on Approach in Patients with Diabetes: A New Robust Method to Assess Inflammation
    Amigo, Nuria
    Fuertes-Martin, Rocio
    Malo, Ana Irene
    Plana, Nuria
    Ibarretxe, Daiana
    Girona, Josefa
    Correig, Xavier
    Masana, Lluis
    LIFE-BASEL, 2021, 11 (12):
  • [27] 1H Nuclear Magnetic Resonance (NMR)-Based Cerebrospinal Fluid and Plasma Metabolomic Analysis in Type 2 Diabetic Patients and Risk Prediction for Diabetic Microangiopathy
    Lin, Huan-Tang
    Cheng, Mei-Ling
    Lo, Chi-Jen
    Lin, Gigin
    Lin, Shu-Fu
    Yeh, Jiun-Ting
    Ho, Hung-Yao
    Lin, Jr-Rung
    Liu, Fu-Chao
    JOURNAL OF CLINICAL MEDICINE, 2019, 8 (06)
  • [28] Quantification of lipoproteins by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves the prediction of cardiac autonomic dysfunction in patients with type 1 diabetes
    Nattero-Chavez, L.
    Insenser, M.
    Amigo, N.
    Samino, S.
    Martinez-Micaelo, N.
    Dorado Avendano, B.
    Quintero Tobar, A.
    Escobar-Morreale, H. F.
    Luque-Ramirez, M.
    JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2024, 47 (08) : 2075 - 2085
  • [29] 1H Nuclear Magnetic Resonance (NMR)-Based Metabolome Diversity of Seabuckthorn (H. rhamnoides L.) Berries Originating from Two Geographical Regions of Indian Himalayas
    Singh, Sugandh
    Sharma, Prakash Chand
    FOOD ANALYTICAL METHODS, 2022, 15 (01) : 157 - 171
  • [30] Quantification of glycoproteins by nuclear magnetic resonance associated with preclinical carotid atherosclerosis in patients with type 1 diabetes
    Seres-Noriega, Tonet
    Gimenez, Marga
    Perea, Veronica
    Blanco, Jesus
    Vinagre, Irene
    Pane, Adriana
    Ruiz, Sabina
    Cofan, Monserrat
    Mesa, Alex
    Esmatjes, Enric
    Conget, Ignacio
    Ortega, Emilio
    Amor, Antonio J.
    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2021, 31 (07) : 2099 - 2108
12345