Cortisol Awakening Response and Hippocampal Volume: Vulnerability for Major Depressive Disorder?

被引:66
作者
Dedovic, Katarina [1 ]
Engert, Veronika [1 ]
Duchesne, Annie [1 ]
Lue, Sonja Damika [1 ]
Andrews, Julie [1 ]
Efanov, Simona I. [1 ]
Beaudry, Thomas [1 ]
Pruessner, Jens C. [2 ]
机构
[1] McGill Univ, Fac Med, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada
[2] McGill Univ, Fac Med, McGill Ctr Studies Aging, Montreal, PQ, Canada
基金
加拿大健康研究院;
关键词
Cortisol awakening response; hippocampus; manual segmentation; subclinical depression; vulnerability; WAKING SALIVARY CORTISOL; STRESS; YOUNG; BRAIN; METAANALYSIS; AMYGDALA; ANXIETY; STATE; RISK; MRI;
D O I
10.1016/j.biopsych.2010.07.025
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: Major depressive disorder is associated with dysregulated basal cortisol levels and small hippocampal (HC) volume. However, it is still debated whether these phenomena are a consequence of the illness or whether they may represent a vulnerability marker existing before the illness onset. Here, we aimed to examine this notion of vulnerability by assessing whether abnormalities in basal cortisol secretion and HC volumes are already present in a sample of healthy young adults who showed varying levels of depressive tendencies, but at subclinical levels. Methods: We recruited healthy young men and women from the local university. On the basis of depression scores derived from standard questionnaires, three groups were formed: a control group (n = 27), a subclinical group (n = 23), and a high-risk subclinical group (n = 9). The participants underwent a magnetic resonance imaging scan and collected saliva samples for the assessment of diurnal cortisol levels. Results: Both the subclinical and the high-risk subclinical group failed to show a significant increase in cortisol levels after awakening. The high-risk subclinical group also showed a lower area-under-the-curve increase of cortisol levels after awakening compared with control subjects. In addition, this group also had smaller total HC volume compared with control subjects. Conclusions: The findings from this subclinical sample suggest that dysregulated cortisol awakening response and small HC volume may constitute vulnerability factors for major depressive disorder. Further investigations are needed to discern the mechanisms that may underlie these phenomena.
引用
收藏
页码:847 / 853
页数:7
相关论文
共 66 条
[1]   Prospective prediction of major depressive disorder from cortisol awakening responses in adolescence [J].
Adam, Emma K. ;
Doane, Leah D. ;
Zinbarg, Richard E. ;
Mineka, Susan ;
Craske, Michelle G. ;
Griffith, James W. .
PSYCHONEUROENDOCRINOLOGY, 2010, 35 (06) :921-931
[2]   DIFFERENTIATING ANXIETY AND DEPRESSION - A TEST OF THE COGNITIVE CONTENT-SPECIFICITY HYPOTHESIS [J].
BECK, AT ;
BROWN, G ;
EIDELSON, JI ;
STEER, RA ;
RISKIND, JH .
JOURNAL OF ABNORMAL PSYCHOLOGY, 1987, 96 (03) :179-183
[3]  
Bernstein D.P., 2003, Childhood Trauma Questionnaire--Short Form, DOI 10.1037/t09716-000
[4]   Increase in concentration of waking salivary cortisol in recovered patients with depression [J].
Bhagwagar, Z ;
Hafizi, S ;
Cowen, PJ .
AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (10) :1890-1891
[5]   Depression and cortisol responses to psychological stress: A meta-analysis [J].
Burke, HM ;
Davis, MC ;
Otte, C ;
Mohr, DC .
PSYCHONEUROENDOCRINOLOGY, 2005, 30 (09) :846-856
[6]   Anatomical MRI study of hippocampus and amygdala in patients with current and remitted major depression [J].
Caetano, SC ;
Hatch, JP ;
Brambilla, P ;
Sassi, RB ;
Nicoletti, M ;
Mallinger, AG ;
Frank, E ;
Kupfer, DJ ;
Keshavan, MS ;
Soares, JC .
PSYCHIATRY RESEARCH-NEUROIMAGING, 2004, 132 (02) :141-147
[7]   An update on regional brain volume differences associated with mood disorders [J].
Campbell, S ;
MacQueen, G .
CURRENT OPINION IN PSYCHIATRY, 2006, 19 (01) :25-33
[8]  
Campbell S, 2004, J PSYCHIATR NEUROSCI, V29, P417
[9]  
CHEN MC, 2009, SOC BIOL PSYCH 64 AN
[10]   Cortisol awakening response and psychosocial factors: A systematic review and meta-analysis [J].
Chida, Yoichi ;
Steptoe, Andrew .
BIOLOGICAL PSYCHOLOGY, 2009, 80 (03) :265-278