Differential response of sebaceous glands to exogenous testosterone

被引：0

作者：

Holland, DB

Cunliffe, WJ

Norris, JFB ^{[1
]}

机构：

[1] Univ Leeds, Gen Infirm, Dept Dermatol, Skin Res Ctr, Leeds LS1 3EX, W Yorkshire, England

[2] Dumfries & Galloway Royal Infirm, Dept Dermatol, Dumfries, Scotland

来源：

BRITISH JOURNAL OF DERMATOLOGY | 1998年 / 139卷 / 01期

关键词：

D O I：

暂无

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

To test the hypothesis that the seborrhoea of acne is an end-organ hyper-response to androgens, a standardized dose of 2% testosterone cream was applied to the forehead of eight prepubertal boys for 6 weeks and the effect determined by measurements of sebum excretion rate (SER). Three boys showed a 15-fold increase in SER and three boys were non-responders, whereas two boys had SER values between those;of the responders and non-responders. These data show that sebaceous glands are stimulated by androgens to varying degrees and support the theory of an end-organ response in acne.

引用

页码：102 / 103

页数：2

共 8 条

[1] CIRCULATING TESTOSTERONE, SEX-HORMONE BINDING GLOBULIN AND PROLACTIN IN WOMEN WITH LATE ONSET OR PERSISTENT ACNE-VULGARIS [J].