The dopamine D-2 receptor (DRD2) gene: A genetic risk factor in smoking

被引：207
作者：
Comings, DE [1 ]
Ferry, L [1 ]
BradshawRobinson, S [1 ]
Burchette, R [1 ]
Chiu, C [1 ]
Muhleman, D [1 ]
机构：
[1] JERRY L PETTIS VET AFFAIRS HOSP, LOMA LINDA, CA USA
来源：
PHARMACOGENETICS | 1996年 / 6卷 / 01期
关键词：
nicotine; smoking; dopamine; DRD2; receptors; addiction; tobacco;
D O I：
10.1097/00008571-199602000-00006
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Of a group of 312 non-Hispanic Caucasians who smoked at least one pack per day, had unsuccessfully attempted to stop smoking, and were free of alcohol or other drug dependence, 48.7% carried the A1 allele of the DRD2 gene. This was significantly greater than the 25.9% prevalence in the 714 known non-Hispanic Caucasian controls without alcohol or drug abuse, p < 10(-8), and significantly greater than in a smaller set of our study controls. There was a significant, inverse relationship between the prevalence of the D(2)A1 allele and the age of onset of smoking, p = 0.02, and the maximum duration of time the smokers had been able to quit smoking on their own, p = 0.02. These results suggest the DRD2 gene is one of a multifactorial set of risk factors associated with smoking.
引用
收藏
页码：73 / 79
页数：7
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