The dopamine D-2 receptor (DRD2) gene: A genetic risk factor in smoking

被引：207

作者：

Comings, DE ^{[1
]}

Ferry, L ^{[1
]}

BradshawRobinson, S ^{[1
]}

Burchette, R ^{[1
]}

Chiu, C ^{[1
]}

Muhleman, D ^{[1
]}

机构：

[1] JERRY L PETTIS VET AFFAIRS HOSP, LOMA LINDA, CA USA

来源：

PHARMACOGENETICS | 1996年 / 6卷 / 01期

关键词：

nicotine; smoking; dopamine; DRD2; receptors; addiction; tobacco;

D O I：

10.1097/00008571-199602000-00006

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Of a group of 312 non-Hispanic Caucasians who smoked at least one pack per day, had unsuccessfully attempted to stop smoking, and were free of alcohol or other drug dependence, 48.7% carried the A1 allele of the DRD2 gene. This was significantly greater than the 25.9% prevalence in the 714 known non-Hispanic Caucasian controls without alcohol or drug abuse, p < 10(-8), and significantly greater than in a smaller set of our study controls. There was a significant, inverse relationship between the prevalence of the D(2)A1 allele and the age of onset of smoking, p = 0.02, and the maximum duration of time the smokers had been able to quit smoking on their own, p = 0.02. These results suggest the DRD2 gene is one of a multifactorial set of risk factors associated with smoking.

引用

页码：73 / 79

页数：7

共 50 条

[21] C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
M Hirvonen
A Laakso
K Någren
J O Rinne
T Pohjalainen
J Hietala
Molecular Psychiatry, 2004, 9 : 1060 - 1061
[22] Possible interaction of MAOA gene with dopamine D2 receptor (DRD2) gene in alcohol dependence
Lu, R
Huang, S
Wang, T
Wu, Y
Ko, H
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S141 - S141
[23] Genetics and smoking cessation: Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and NRT
Lerman, CE
Jepson, C
Wileyto, EP
Epstein, L
Rukstalis, M
Patterson, F
Kaufmann, V
Hawk, L
Restine, S
Niaura, R
Berrettini, W
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2004, 13 (11) : 1958S - 1959S
[24] Association of polymorphisms of dopamine D-2 receptor (DRD2), and dopamine transporter (DAT(1)) genes with schizoid/avoidant behaviors (SAB)
Blum, K
Braverman, ER
Wu, S
Cull, JG
Chen, TJH
Gill, J
Wood, R
Eisenberg, A
Sherman, M
Davis, KR
Matthews, D
Fischer, L
Schnautz, N
Walsh, W
Pontius, AA
Zedar, M
Kaats, G
Comings, DE
MOLECULAR PSYCHIATRY, 1997, 2 (03) : 239 - 246
[25] Association between D2 Dopamine Receptor(DRD2) gene and posttraumatic stress disorder
Chung, H.
Kim, T.
Choi, J.
So, H.
Kang, S.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2014, 17 : 111 - 111
[26] The DRD2 gene, smoking, and lung cancer
Noble, EP
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (05): : 343 - 345
[27] Erratum: C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
M Hirvonen
A Laakso
K Någren
J O Rinne
T Pohjalainen
J Hietala
Molecular Psychiatry, 2005, 10 : 889 - 889
[28] Molecular variation within the dopamine receptor DRD2 gene in migraine
Stephen J. Peroutka
The Journal of Headache and Pain, 2000, 1 (Suppl 2) : S147 - S151
[29] No association between D2 dopamine receptor (DRD2) "A" system alleles, or DRD2 haplotypes, and posttraumatic stress disorder
Gelernter, J
Southwick, S
Goodson, S
Morgan, A
Nagy, L
Charney, DS
BIOLOGICAL PSYCHIATRY, 1999, 45 (05) : 620 - 625
[30] Dopamine receptor genes (DRD2, DRD3 and DRD4) and gene-gene interactions associated with smoking-related behaviors
Vandenbergh, David J.
O'Connor, Richard J.
Grant, Michael D.
Jefferson, Akilah L.
Vogler, George P.
Strasser, Andrew A.
Kozlowski, Lynn T.
ADDICTION BIOLOGY, 2007, 12 (01) : 106 - 116

← 1 2 3 4 5 →