Amelioration of Dextran Sulfate Sodium-Induced Experimental Ulcer Colitis in Mice by Bacillus licheniformis

被引：0

作者：

Yao, Di-Fei ^{[1
]}

Chen, Zhong-Ting ^{[1
]}

Pan, Wen-Sheng ^{[2
]}

Xu, Xiang ^{[1
]}

Lan, Mei-Juan ^{[3
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Pharm, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gastroenterol, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2014年 / 33卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Bacillus licheniformis; BRP-39; CD44; IL-13; Ulcerative colitis; INFLAMMATORY-BOWEL-DISEASE; NF-KAPPA-B; CHITINASE; 3-LIKE-1; EPITHELIAL-CELLS; CD44; PEPTIDOGLYCAN; APOPTOSIS; ADHESION; YKL-40; MUCOSA;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to investigate the possible protective role of Bacillus licheniformis (BL) in a murine model of ulcerative colitis (UC). The UC mice were treated with different doses of BL or sulfasalazine. Control group received tap water only. Macroscopic assessment, as well as colonic histological assessment was graded. The expression of breast regression protein-39 (BRP-39), interleukin 13 (IL-13), CD44, nuclear factor kappa B (NF-kappa B) and B cell lymphoma 2 (Bcl-2) in colons of mice were measured by RT-PCR and immunohistochemistry. A significant improvement was observed in disease activity index (DAI) and histological score in mice treated with high dose BL. The expression of BRP-39, IL-13, CD44, NF-kappa B and Bcl-2 in colons of UC mice was reduced following administration of high dose BL. BL could ameliorate dextran sulfate sodium induced experimental UC in mice, possibly by decreasing the secretion of BRP-39, IL-13, CD44, NF-kappa B and Bcl-2 in colon.

引用

页码：1690 / 1698

页数：9

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