Diastereoselective synthesis of fluorinated, seven-membered β-amino acid derivatives via ring-closing metathesis

被引：56

作者：

Fustero, S ^{[1
]}

Bartolomé, A ^{[1
]}

Sanz-Cervera, JF ^{[1
]}

Sánchez-Roselló, M ^{[1
]}

Soler, JG ^{[1
]}

de Arellano, CR ^{[1
]}

Fuentes, AS ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 14期

关键词：

D O I：

10.1021/ol034827k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Cis and trans seven-membered gamma,gamma-difluorinated beta-amino acid derivatives (III) have been prepared with a sequence that starts with imidoyl halides (I), which are condensed with suitable ester enolates to give intermediates (II). These, in turn, can be cyclized by means of a ringclosing olefin metathesis reaction and the product stereoselectively reduced to yield compounds (III) in good overall yields.

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页码：2523 / 2526

页数：4

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