Graft-versus-tumour effect in non-small-cell lung cancer after allogeneic peripheral blood stem cell transplantation

被引：27

作者：

Moscardó, F

Martínez, JA

Sanz, GF

Jiménez, C

Cervera, J

Sanchís, J

Vera, FJ

Sanz, MA

机构：

[1] Hosp Univ La Fe, Dept Haematol, Valencia 46009, Spain

[2] Hosp Univ La Fe, Dept Pneumol, Valencia 46009, Spain

[3] Hosp Univ La Fe, Dept Pathol, Valencia 46009, Spain

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 111卷 / 02期

关键词：

graft-vs.-tumour-effect; lung cancer; allogeneic stem cell transplantation;

D O I：

10.1046/j.1365-2141.2000.02368.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Clinical evidence of a graft-vs.-tumour effect in solid tumours after haematopoietic stem cell transplantation is lacking. We report for the first time a complete and durable regression of a stage IB non-small-cell lung carcinoma in a patient who had received an allogeneic peripheral blood haematopoietic stem cell transplant for acute myeloblastic leukaemia in first complete remission. Disappearance of the tumour coincided with development of graft-vs.-host disease. This suggests that simultaneous generation of cytotoxic T lymphocytes against lung carcinoma cells could have been responsible for the regression. This unique clinical observation broadens the possibility of using allogeneic haematopoietic stem cell transplantation in treating neoplasias lacking significant sensitivity to chemotherapy.

引用

页码：708 / 710

页数：3

共 11 条

[1]

BUTTURINI A, 1987, BONE MARROW TRANSPL, V2, P233

[2] Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation [J].

Collins, RH ;

Shpilberg, O ;

Drobyski, WR ;

Porter, DL ;

Giralt, S ;

Champlin, R ;

Goodman, SA ;

Wolff, SN ;

Hu, W ;

Verfaillie, C ;

List, A ;

Dalton, W ;

Ognoskie, N ;

Chetrit, A ;

Antin, JH ;

Nemunaitis, J .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (02) :433-444

[3]

DANIEL C, 1992, NEW ENGL J MED, V12, P1434

[4] Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer [J].

Eibl, B ;

Schwaighofer, H ;

Nachbaur, D ;

Marth, C ;

Gachter, A ;

Knapp, R ;

Bock, G ;

Gassner, C ;

Schiller, L ;

Petersen, F ;

Niederwieser, D .

BLOOD, 1996, 88 (04) :1501-1508

[5]

HOROWITZ MM, 1990, BLOOD, V75, P555

[6] Revisions in the International System for Staging Lung Cancer [J].

Mountain, CF .

CHEST, 1997, 111 (06) :1710-1717

[7]

Shepherd FA, 1999, SEMIN ONCOL, V26, P3

[8] Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases [J].

Slavin, S ;

Nagler, A ;

Naparstek, E ;

Kapelushnik, Y ;

Aker, M ;

Cividalli, G ;

Varadi, G ;

Kirschbaum, M ;

Ackerstein, A ;

Samuel, S ;

Amar, A ;

Brautbar, C ;

Ben-Tal, O ;

Eldor, A ;

Or, R .

BLOOD, 1998, 91 (03) :756-763

[9] Management of lymphoma recurrence after allogeneic transplantation: The relevance of graft-versus-lymphoma effect [J].

vanBesien, KW ;

deLima, M ;

Giralt, SA ;

Moore, DF ;

Khouri, IF ;

Rondon, G ;

Mehra, R ;

Andersson, BS ;

Dyer, C ;

Cleary, K ;

Przepiorka, D ;

Gajewski, JL ;

Champlin, RE .

BONE MARROW TRANSPLANTATION, 1997, 19 (10) :977-982

[10] Graft-versus-myeloma effect in two cases [J].

Verdonck, LF ;

Lokhorst, HM ;

Dekker, AW ;

Nieuwenhuis, HK ;

Petersen, EJ .

LANCET, 1996, 347 (9004) :800-801

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