Angiotensin-II-derived reactive oxygen species on baroreflex sensitivity during hypertension: new perspectives

被引：32
作者：
de Queiroz, Thyago M. [1 ]
Monteiro, Matheus M. O. [1 ]
Braga, Valdir A. [1 ]
机构：
[1] Univ Fed Paraiba, Biotechnol Ctr, Dept Biotechnol, BR-58051970 Joao Pessoa, Paraiba, Brazil
来源：
FRONTIERS IN PHYSIOLOGY | 2013年 / 4卷
关键词：
hypertension; antioxidants; angiotensin-II; NADPH oxidase; baroreflex; ROSTRAL VENTROLATERAL MEDULLA; OXIDATIVE STRESS; NADPH OXIDASE; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT TREATMENT; SUPEROXIDE-PRODUCTION; RECEPTOR EXPRESSION; NAD(P)H OXIDASE; AT(2) RECEPTORS;
D O I：
10.3389/fphys.2013.00105
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Hypertension IS a multifactorial disorder, which has been associated with the reduction in baroreflex sensitivity (BRS) and autonomic dysfunction. Several studies have revealed that increased reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate [NAD(P)H] oxidase, following activation of type 1 receptor (ATi R) by Angiotensin-(Ang) II, the main peptide of the Renin Angiotensin Aldosterone System (RAAS), is the central mechanism involved in Ang-II-derived hypertension. In the present review, we will discuss the role of Ang II and oxidative stress in hypertension, the relationship between the BPS and the genesis of hypertension and how the oxidative stress triggers baroreflex dysfunction in several models of hypertension. Finally, we will describe some novel therapeutic drugs for improving the BRS during hypertension.
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页数：6
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