Effect of myricetin on cognitive impairments in the transgenic Drosophila model of Parkinson's Disease

被引：0
作者：
Ara, Gulshan [1 ]
Afzal, Mohammad [1 ]
Naz, Falaq [1 ]
Mantasha, I [2 ]
Shahid, M. [2 ]
Siddique, Yasir Hasan [1 ]
机构：
[1] Aligarh Muslim Univ AMU, Sect Genet, Dept Zool, Fac Life Sci, Aligarh 202002, Uttar Pradesh, India
[2] Aligarh Muslim Univ AMU, Fac Sci, Dept Chem, Aligarh 202002, Uttar Pradesh, India
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2022年 / 60卷 / 01期
关键词：
Molecular docking; Neurodegenerative disorder; alpha-Synuclein; ALPHA-SYNUCLEIN; FIBRILLATION; FLAVONOIDS;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Parkinson's Disease (PD) is a progressive neurodegenerative disorder involving the loss of dopaminergic neurons. Despite the availability of many drugs to ease the life of PD patients, there is no permanent cure until now. Now-a-days, there has been a considerable attention towards the use of herbal products to treat PD patients worldwide due to less side effects. In this context, here we investigated myricetin, a common plant derived flavonoid, on the cognitive impairments exhibited by the transgenic Drosophila expressing human alpha-synuclein in the neurons. The PD flies were allowed to feed on the diet having 10, 20 and 40 mu M of myricetin for 24 days and then assayed for cognitive impairments. The exposure of myricetin showed a dose dependent significant delay in the cognitive impairments. Molecular docking studies showed the positive interaction between myricetin and alpha-synuclein. The results suggest a protective effect of myricetin against the cognitive impairments.
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页码：27 / 33
页数：7
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