Plasma Amyloid-β dynamics in late-life major depression: a longitudinal study

被引:17
作者
Pomara, Nunzio [1 ,2 ]
Bruno, Davide [3 ]
Plaska, Chelsea Reichert [1 ,4 ]
Ramos-Cejudo, Jaime [4 ]
Osorio, Ricardo S. [1 ,4 ]
Pillai, Anilkumar [5 ,6 ,7 ]
Imbimbo, Bruno P. [8 ]
Zetterberg, Henrik [9 ,10 ,11 ,12 ,13 ]
Blennow, Kaj [11 ,12 ]
机构
[1] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA
[2] NYU, Dept Psychiat & Pathol, Grossman Sch Med, New York, NY 10016 USA
[3] Liverpool John Moores Univ, Sch Psychol, Liverpool, Merseyside, England
[4] NYU, Dept Psychiat, Grossman Sch Med, 550 1St Ave, New York, NY 10016 USA
[5] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Pathophysiol Neuropsychiat Disorders Program, Houston, TX USA
[6] Charlie Norwood VA Med Ctr, Res & Dev, Augusta, GA USA
[7] Augusta Univ, Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA USA
[8] Chiesi Farmaceut, Res & Dev, Parma, Italy
[9] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England
[10] UK Dementia Res Inst UCL, London, England
[11] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
[12] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
[13] Hong Kong Ctr Neurodegenerat Dis, Clear Water Bay, Hong Kong, Peoples R China
基金
瑞典研究理事会; 欧洲研究理事会;
关键词
ALZHEIMER-DISEASE; COGNITIVE DECLINE; RISK-FACTOR; EARLY-ONSET; SYMPTOMS; DEPOSITION; HISTORY; DEMENTIA; PLAQUES; TANGLES;
D O I
10.1038/s41398-022-02077-8
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Depressed individuals are twice as likely to develop Alzheimer's disease (AD) as compared to controls. Brain amyloid-beta (A beta) deposition is believed to have a major role in AD pathogenesis but studies also suggest associations of A beta dynamics and depression. The aim of this study was to test if plasma A beta levels are longitudinally associated to late-life depression. We measured plasma levels of amyloid-beta(1-40) (A beta 40) and amyloid-beta(1-42) (A beta 42) peptides longitudinally for three consecutive years in 48 cognitively intact elderly subjects with late-life major depressive disorder (LLMD) and 45 age-matched cognitively healthy controls. We found that the A beta 42/A beta 40 plasma ratio was significantly and steadily lower in depressed subjects compared to controls (p < 0.001). At screening, A beta 42/A beta 40 plasma did not correlate with depression severity (as measured with Hamilton Depression Scale) or cognitive performance (as measured with Mini-Mental State Examination) but was associated to depression severity at 3 years after adjustment for age, education, cognitive performance, and antidepressants use. This study showed that reduced plasma A beta 42/A beta 40 ratio is consistently associated with LLMD diagnosis and that increased severity of depression at baseline predicted low A beta 42/A beta 40 ratio at 3 years. Future studies are needed to confirm these findings and examine if the consistently lower plasma A beta 42/A beta 40 ratio in LLMD reflects increased brain amyloid deposition, as observed in AD subjects, and an increased risk for progressive cognitive decline and AD.
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页数:7
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