Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis

被引：18

作者：

Appendino, G

Aviello, G

Ballero, M

Borrelli, F

Fattorusso, E

Petrucci, F

Santelia, FU

Taglialatela-Scafati, O

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dipartimenot Farmacol Sperimentale, I-80131 Naples, Italy

[3] Univ Piemonte Orientale, DISCAFF, I-28100 Novara, Italy

[4] Univ Cagliari, Dipartimento Sci Bot, I-09123 Cagliari, Italy

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 06期

关键词：

D O I：

10.1021/np050120q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

引用

页码：853 / 857

页数：5

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