Lateralized effects of subthalamic nucleus stimulation on different aspects of speech in Parkinson's disease

被引：72

作者：

Santens, P

De Letter, M

Van Borsel, J

De Reuck, J

Caemaert, J

机构：

[1] Ghent Univ Hosp, Dept Neurol, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Dept Otorhinolaryngol, B-9000 Ghent, Belgium

[3] Ghent Univ Hosp, Dept Neurosurg, B-9000 Ghent, Belgium

来源：

BRAIN AND LANGUAGE | 2003年 / 87卷 / 02期

关键词：

Parkinson; STN stimulation; lateralization; prosody; articulation; intelligibility; voice; loudness; speech rate; basal ganglia;

D O I：

10.1016/S0093-934X(03)00142-1

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

In this report, we have analyzed the effects of left and right STN stimulation separately on different aspects of speech. Significant differences were found between left and right stimulation. It appears that selective left-sided stimulation has a profoundly negative effect on prosody, articulation and hence intelligibility. Right-sided stimulation does not display this side-effect. There is no significant difference in speech characteristics between bilateral stimulation on and off. We suggest that a balanced tuning of bilateral basal ganglia networks is necessary for speech, and that the left circuit is probably dominant. (C) 2003 Published by Elsevier Science (USA).

引用

页码：253 / 258

页数：6

共 27 条

[1] Deep brain stimulation in Parkinson's disease: Opposite effects of stimulation in the pallidum [J].