The Prognostic Significance of Soluble Programmed Death Ligand 1 Expression in Cancers: A Systematic Review and Meta-analysis

被引：40
作者：
Ding, Y. [1 ]
Sun, C. [2 ]
Li, J. [3 ]
Hu, L. [1 ]
Li, M. [1 ]
Liu, J. [1 ]
Pu, L. [4 ]
Xiong, S. [1 ]
机构：
[1] Anhui Med Univ, Dept Hematol, Hosp 2, Hematol Lab, Lotus Rd 678, Hefei 230601, Anhui, Peoples R China
[2] Anhui Med Univ, Dept Pharmacol, Hosp 2, Hefei, Anhui, Peoples R China
[3] Anhui Med Univ, Dept Emergency, Hosp 2, Hefei, Anhui, Peoples R China
[4] Third Peoples Hosp Bengbu, Dept Hematol, Bengbu, Anhui, Peoples R China
来源：
SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2017年 / 86卷 / 05期
基金：
美国国家科学基金会;
关键词：
CELL LUNG-CANCER; PD-L1; EXPRESSION; CIRCULATING PD-L1; SOLID TUMORS; SURVIVAL; LEVEL; BIOMARKER; MEMBER;
D O I：
10.1111/sji.12596
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The differential expression of soluble programmed death ligand 1 (sPD-L1) has been found in some cancers; however, the correlation between sPD-L1 expression and prognosis value in tumour is still unclear. Here, we conducted a meta-analysis and systematic review to assess the prognostic value of sPD-L1 in patients with cancer. Eligible studies were searched for in the databases including PubMed, Web of Science, ScienceDirect and Wiley Online Library database. The pooled hazard ratios (HRs) with a 95% confidence interval (95%CI) were calculated to assess the prognostic significance of sPD-L1 in human cancer. Eight studies and 1102 patients with cancer were included in the final analysis, and the combined analysis indicated that a higher level of sPD-L1 was associated with worse overall survival (OS) (HR = 1.60, 95%CI: 1.21-1.99). Furthermore, statistical significance was also observed in subgroup analysis stratified by the cancer type (haematological neoplasms or non-haematological neoplasms), sample size (more or less than 100), cut-off value of sPD-L1 (more or less than 6.51 ng/ml) and ethnicity (Asian or European). The meta-analysis indicates that circulating sPD-L1 changes may serve as a useful biomarker for cancer prognosis, and higher level of sPD-L1 may also be associated with poor outcomes in patients with cancer.
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收藏
页码：361 / 367
页数：7
相关论文
共 29 条
[1]   The role of PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: a network meta-analysis [J].
Aguiar, Pedro N., Jr. ;
Santoro, Ilka Lopes ;
Tadokoro, Hakaru ;
Lopes, Gilberto de Lima ;
Filardi, Bruno Andraus ;
Oliveira, Pedro ;
Mountzios, Giannis ;
de Mello, Ramon Andrade .
IMMUNOTHERAPY, 2016, 8 (04) :479-488
[2]   Development of a sandwich ELISA for evaluating soluble PD-L1 (CD274) in human sera of different ages as well as supernatants of PD-L1+ cell lines [J].
Chen, Yongjing ;
Wang, Qin ;
Shi, Bimin ;
Xu, Ping ;
Hu, Zhenhua ;
Bai, Lixiong ;
Zhang, Xueguang .
CYTOKINE, 2011, 56 (02) :231-238
[3]   Tumor PD-L1 expression is correlated with increased TILs and poor prognosis in penile squamous cell carcinoma [J].
Deng, Chuangzhong ;
Li, Zaishang ;
Guo, Shengjie ;
Chen, Peng ;
Chen, Xiaofeng ;
Zhou, Qianghua ;
Chen, Jieping ;
Yu, Xingsu ;
Wu, Xiaoliang ;
Ma, Wenjuan ;
Xie, Qiankun ;
Ye, Yunlin ;
Li, Yonghong ;
Qin, Zike ;
Liu, Zhuowei ;
Liu, Ranyi ;
Zhang, Zhenfeng ;
Yao, Kai ;
Han, Hui ;
Zhou, Fangjian .
ONCOIMMUNOLOGY, 2017, 6 (02)
[4]  
Dong HD, 1999, NAT MED, V5, P1365
[5]   High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis [J].
Finkelmeier, Fabian ;
Canli, Oezge ;
Tal, Andrea ;
Pleli, Thomas ;
Trojan, Joerg ;
Schmidt, Michael ;
Kronenberger, Bernd ;
Zeuzem, Stefan ;
Piiper, Albrecht ;
Greten, Florian R. ;
Waidmann, Oliver .
EUROPEAN JOURNAL OF CANCER, 2016, 59 :152-159
[6]   Identification of a Soluble Form of B7-H1 That Retains Immunosuppressive Activity and Is Associated with Aggressive Renal Cell Carcinoma [J].
Frigola, Xavier ;
Inman, Brant A. ;
Lohse, Christine M. ;
Krco, Christopher J. ;
Cheville, John C. ;
Thompson, R. Houston ;
Leibovich, Bradley ;
Blute, Michael L. ;
Dong, Haidong ;
Kwon, Eugene D. .
CLINICAL CANCER RESEARCH, 2011, 17 (07) :1915-1923
[7]   Soluble programmed death-ligand 1 (sPDL1) and neutrophil-to-lymphocyte ratio (NLR) predicts survival in advanced biliary tract cancer patients treated with palliative chemotherapy [J].
Ha, Hyerim ;
Nam, Ah-Rong ;
Bang, Ju-Hee ;
Park, Ji-Eun ;
Kim, Tae-Yong ;
Lee, Kyung-Hun ;
Han, Sae-Won ;
Im, Seock-Ah ;
Kim, Tae-You ;
Bang, Yung-Jue ;
Oh, Do-Youn .
ONCOTARGET, 2016, 7 (47) :76604-76612
[8]   Prognostic Role of PD-L1 Expression in Renal Cell Carcinoma. A Systematic Review and Meta-Analysis [J].
Iacovelli, Roberto ;
Nole, Franco ;
Verri, Elena ;
Renne, Giuseppe ;
Paglino, Chiara ;
Santoni, Matteo ;
Rocca, Maria Cossu ;
Giglione, Palma ;
Aurilio, Gaetano ;
Cullura, Daniela ;
Cascinu, Stefano ;
Porta, Camillo .
TARGETED ONCOLOGY, 2016, 11 (02) :143-148
[9]   INDUCED EXPRESSION OF PD-1, A NOVEL MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY, UPON PROGRAMMED CELL-DEATH [J].
ISHIDA, Y ;
AGATA, Y ;
SHIBAHARA, K ;
HONJO, T .
EMBO JOURNAL, 1992, 11 (11) :3887-3895
[10]   Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade [J].
Iwai, Y ;
Ishida, M ;
Tanaka, Y ;
Okazaki, T ;
Honjo, T ;
Minato, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (19) :12293-12297
123