Longitudinal evidence for diminished frontal cortex function in aging

被引：214

作者：

Nyberg, Lars ^{[1
,2
,3
]}

Salami, Alireza ^{[1
,3
]}

Andersson, Mikael ^{[1
,3
]}

Eriksson, Johan ^{[1
,3
]}

Kalpouzos, Gregoria ^{[1
,3
]}

Kauppi, Karolina ^{[1
,3
]}

Lind, Johanna ^{[4
,5
,6
]}

Pudas, Sara ^{[3
,5
,6
]}

Persson, Jonas ^{[5
,6
]}

Nilsson, Lars-Goran ^{[5
,6
]}

机构：

[1] Umea Univ, Dept Integrat Med Biol Physiol, S-90187 Umea, Sweden

[2] Umea Univ, Dept Radiat Sci Diagnost Radiol, S-90187 Umea, Sweden

[3] Umea Ctr Funct Brain Imaging, S-90187 Umea, Sweden

[4] Univ Oslo, Dept Psychol, Ctr Study Human Cognit, N-0317 Oslo, Norway

[5] Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden

[6] Stockholm Univ, Stockholm Brain Inst, S-10691 Stockholm, Sweden

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 52期

关键词：

attrition; frontal lobe; multimodal; reorganization; BRAIN ACTIVITY; ATTENTIONAL CONTROL; PROSPECTIVE COHORT; NEURAL MECHANISMS; WORKING-MEMORY; OLDER ADULTS; AGE; ASYMMETRY; COGNITION; DECLINE;

D O I：

10.1073/pnas.1012651108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cross-sectional estimates of age-related changes in brain structure and function were compared with 6-y longitudinal estimates. The results indicated increased sensitivity of the longitudinal approach as well as qualitative differences. Critically, the cross-sectional analyses were suggestive of age-related frontal overrecruitment, whereas the longitudinal analyses revealed frontal underrecruitment with advancing age. The cross-sectional observation of overrecruitment reflected a select elderly sample. However, when followed over time, this sample showed reduced frontal recruitment. These findings dispute inferences of true age changes on the basis of age differences, hence challenging some contemporary models of neurocognitive aging, and demonstrate age-related decline in frontal brain volume as well as functional response.

引用

页码：22682 / 22686

页数：5

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