The expanding role of genetics in epilepsy

被引：0
作者：
Leppik, IE [1 ]
机构：
[1] MINCEP Epilepsy Care, Minneapolis, MN 55416 USA
来源：
AMERICAN JOURNAL OF ELECTRONEURODIAGNOSTIC TECHNOLOGY | 2003年 / 43卷 / 02期
关键词：
antiepileptic drugs; chromosomes; epilepsy; epileptic syndromes; genetics; isoenzymes in the liver; juvenile myoclonic epilepsy; seizures;
D O I：
10.1080/1086508X.2003.11079422
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
New discoveries in genetics promise breakthroughs in both the diagnosis and the treatment of generalized epilepsy. Benign familial convulsions and juvenile myoclonic epilepsy are examples of inheritable epileptic syndromes in which the genetic defect has been identified. It appears that in most generalized epilepsies there is an alteration of the chloride, sodium, or calcium channels. Identification of the specific metabolic error now permits treatment with medications that act specifically on that error. Since most antiepileptic drugs are metabolized by the liver, genetic profiles may permit physicians to prescribe appropriate drug dosages, without the trial and error necessary today.
引用
收藏
页码：70 / 73
页数：4
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