An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era

被引:28
作者
Pascual-Iglesias, Alejandro [1 ,2 ]
Canton, Javier [3 ]
Ortega-Prieto, Ana Maria [4 ]
Jimenez-Guardeno, Jose M. [4 ]
Regla-Nava, Jose Angel [5 ,6 ]
机构
[1] La Paz Univ Hosp, IdiPAZ, Innate Immune Response Grp, Madrid 28046, Spain
[2] La Paz Univ Hosp, IdiPAZ, Tumor Immunol Lab, Madrid 28046, Spain
[3] Int Inst Def & Secur CISDE, Seville 41007, Spain
[4] Kings Coll London, Sch Immunol & Microbial Sci, Dept Infect Dis, London SE1 9RT, England
[5] Ctr Infect Dis & Vaccine Res, La Jolla Inst Immunol, La Jolla, CA 92037 USA
[6] Univ Guadalajara, Univ Ctr Hlth Sci CUCS, Dept Pathol & Microbiol, Guadalajara 44340, Mexico
来源
PATHOGENS | 2021年 / 10卷 / 08期
关键词
coronavirus; SARS-CoV-2; COVID-19; vaccine; clinical trial; pandemic; RESPIRATORY SYNCYTIAL VIRUS; ANIMAL-MODELS; CORONAVIRUS INFECTION; SARS; MERS; DISEASE; SAFETY; PATHOGENESIS; MUTATIONS; COUNTRIES;
D O I
10.3390/pathogens10081030
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants.
引用
收藏
页数:21
相关论文
共 50 条
  • [41] Role of SARS-CoV-2 mutations in the evolution of the COVID-19 pandemic
    Colson, Philippe
    Chaudet, Herve
    Delerce, Jeremy
    Pontarotti, Pierre
    Levasseur, Anthony
    Fantini, Jacques
    La Scola, Bernard
    Devaux, Christian
    Raoult, Didier
    JOURNAL OF INFECTION, 2024, 88 (05)
  • [42] Preventive Medicinal Plants and their Phytoconstituents against SARS-CoV-2/COVID-19
    Nema, Neelesh Kumar
    Mamdapur, Ghouse Modin Nabeesab
    Sarojam, Smitha
    Khamborkar, Swapnil Devidas
    Sajan, Linson Cheruveettil
    Sabu, Sachithra
    Chacko, Baby Kumaranthara
    Jacob, Viju
    PHARMACOGNOSY RESEARCH, 2021, 13 (04): : 173 - 191
  • [43] SARS-CoV-2 (COVID-19) and cystic fibrosis
    Stanton, Bruce A.
    Hampton, Thomas H.
    Ashare, Alix
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2020, 319 (03) : L408 - L415
  • [44] Mapping the technological landscape of SARS, MERS, and SARS-CoV-2 vaccines
    Nascimento Junior, Jose Adao Carvalho
    Santos, Anamaria Mendonca
    Cavalcante, Rafael Ciro Marques
    Quintans-Junior, Lucindo Jose
    Walker, Cristiani Isabel Bandero
    Borges, Lysandro Pinto
    Frank, Luiza Abrahao
    Serafini, Mairim Russo
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2021, 47 (04) : 673 - 684
  • [45] SARS-CoV-2: The Monster Causes COVID-19
    Song, Chang
    Li, Zesong
    Li, Chen
    Huang, Meiying
    Liu, Jianhong
    Fang, Qiuping
    Cao, Zitong
    Zhang, Lin
    Gao, Pengbo
    Nie, Wendi
    Luo, Xueyao
    Kang, Jianhao
    Xie, Shimin
    Lyu, Jianxin
    Zhu, Xiao
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 12
  • [46] Application of Nanobiotechnology for Early Diagnosis of SARS-CoV-2 Infection in the COVID-19 Pandemic
    Sheervalilou, Roghayeh
    Shirvaliloo, Milad
    Sargazi, Saman
    Shirvalilou, Sakine
    Shahraki, Omolbanin
    Pilehvar-Soltanahmadi, Younes
    Sarhadi, Alireza
    Nazarlou, Ziba
    Ghaznavi, Habib
    Khoei, Samideh
    APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2021, 105 (07) : 2615 - 2624
  • [47] Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review
    Fiolet, Thibault
    Kherabi, Yousra
    MacDonald, Conor-James
    Ghosn, Jade
    Peiffer-Smadja, Nathan
    CLINICAL MICROBIOLOGY AND INFECTION, 2022, 28 (02) : 202 - 221
  • [48] Insights into the immune responses of SARS-CoV-2 in relation to COVID-19 vaccines
    Heedo Park
    Mee Sook Park
    Jong Hyeon Seok
    Jaehwan You
    Jineui Kim
    Jeonghun Kim
    Man-Seong Park
    Journal of Microbiology, 2022, 60 : 308 - 320
  • [49] SARS-CoV-2 Variants, Current Vaccines and Therapeutic Implications for COVID-19
    Liang, Hong-Yu
    Wu, Yuyan
    Yau, Vicky
    Yin, Huan-Xin
    Lowe, Scott
    Bentley, Rachel
    Ahmed, Mubashir Ayaz
    Zhao, Wenjing
    Sun, Chenyu
    VACCINES, 2022, 10 (09)
  • [50] Insights into the immune responses of SARS-CoV-2 in relation to COVID-19 vaccines
    Park, Heedo
    Park, Mee Sook
    Seok, Jong Hyeon
    You, Jaehwan
    Kim, Jineui
    Kim, Jeonghun
    Park, Man-Seong
    JOURNAL OF MICROBIOLOGY, 2022, 60 (03) : 308 - 320