Iron out KRAS-driven cancer

被引：2

作者：

Lei, Guang ^{[1
,2
,3
]}

Gan, Boyi ^{[3
]}

机构：

[1] Cent South Univ, Hunan Canc Hosp, Dept Radiat Oncol, Changsha, Hunan, Peoples R China

[2] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2022年 / 219卷 / 04期

关键词：

D O I：

10.1084/jem.20212166

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How to specifically target oncogenic KRAS-driven cancers while sparing normal tissues remains an unmet need in cancer therapy. In this issue of JEM, Jiang et al. (2022. J. Exp. Med.) leveraged KRAS-induced iron addiction in cancer cells to design a clever drug delivery approach to enable selective inhibition of KRAS signaling in mutant KRAS tumors but not in normal tissues, offering a new strategy for treating this largely incurable disease.

引用

页数：3

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