A neuroprotective sulfone of marine origin and the in vivo anti-inflammatory activity of an analogue

被引：56

作者：

Wen, Zhi-Hong ^{[1
,2
]}

Chao, Chih-Hua ^{[1
]}

Wu, Ming-Hsuan ^{[1
]}

Sheu, Jyh-Horng ^{[1
,2
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 12期

关键词：

Austrasulfone; Dihydroaustrasulfone alcohol; Cladiella australis; Neuroprotection; Anti-inflammatory; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CORAL CLADIELLA-AUSTRALIS; NITRIC-OXIDE SYNTHASE; SOFT CORAL; ECTEINASCIDIA-TURBINATA; MULTIPLE-SCLEROSIS; CARIBBEAN TUNICATE; NEUROPATHIC PAIN; SMOOTH-MUSCLE; INJURY;

D O I：

10.1016/j.ejmech.2010.09.067

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Our continuing effort of searching bioactive substances from the Formosan soft coral Cladiella australis has led to the isolation of a bioactive substance austrasulfone (1), which possesses significant neuroprotective activities. A straightforward synthesis of 1 was achieved by a two-step reaction sequence. Dihydroaustrasulfone alcohol (3), the synthetic precursor of 1, not only exhibited in vitro anti-inflammatory activity, but also showed potent therapeutic ability in the treatment of neuropathic pain, atherosclerosis, and multiple sclerosis in rats. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：5998 / 6004

页数：7