A neuroprotective sulfone of marine origin and the in vivo anti-inflammatory activity of an analogue

被引：56
作者：
Wen, Zhi-Hong [1 ,2 ]
Chao, Chih-Hua [1 ]
Wu, Ming-Hsuan [1 ]
Sheu, Jyh-Horng [1 ,2 ]
机构：
[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan
[2] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 12期
关键词：
Austrasulfone; Dihydroaustrasulfone alcohol; Cladiella australis; Neuroprotection; Anti-inflammatory; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CORAL CLADIELLA-AUSTRALIS; NITRIC-OXIDE SYNTHASE; SOFT CORAL; ECTEINASCIDIA-TURBINATA; MULTIPLE-SCLEROSIS; CARIBBEAN TUNICATE; NEUROPATHIC PAIN; SMOOTH-MUSCLE; INJURY;
D O I：
10.1016/j.ejmech.2010.09.067
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Our continuing effort of searching bioactive substances from the Formosan soft coral Cladiella australis has led to the isolation of a bioactive substance austrasulfone (1), which possesses significant neuroprotective activities. A straightforward synthesis of 1 was achieved by a two-step reaction sequence. Dihydroaustrasulfone alcohol (3), the synthetic precursor of 1, not only exhibited in vitro anti-inflammatory activity, but also showed potent therapeutic ability in the treatment of neuropathic pain, atherosclerosis, and multiple sclerosis in rats. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：5998 / 6004
页数：7
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