Cellular interactions in prostate cancer genesis and dissemination. Looking beyond the obvious

被引：0

作者：

Tomuleasa, C. ^{[1
]}

Kacso, G. ^{[2
]}

Soritau, Olga ^{[1
]}

Susman, S. ^{[3
]}

Irimie, A. ^{[4
]}

Virag, Piroska ^{[1
]}

机构：

[1] Ion Chiricuta Comprehens Canc Ctr, Dept Canc Immunol, Cluj Napoca 400015, Romania

[2] Ion Chiricuta Comprehens Canc Ctr, Dept Radiat Oncol, Cluj Napoca 400015, Romania

[3] Iuliu Hatieganu Univ Med & Pharm, Dept Histol, Cluj Napoca 400023, Romania

[4] Ion Chiricuta Comprehens Canc Ctr, Dept Surg, Cluj Napoca 400015, Romania

来源：

ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY | 2010年 / 51卷 / 03期

关键词：

prostate cancer stem cells; stem cell niche; cell plasticity; STEM-CELLS; IN-VIVO; TUMOR-METASTASIS; BREAST-CANCER; LUNG-CANCER; CARCINOMA; INHIBITION; PROTEINS; PATHWAYS; FUSION;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Similar to normal organs arising from normal stem cells, cancers can be viewed as organs composed of heterogeneous cellular populations arising from cancer cells with indefinite proliferation abilities. The continuous malignant progression is maintained by the proliferation of cancer stem cells and not the progeny that undergo limited proliferation before terminally differentiating. Effective therapy must eradicate malignant cells with unlimited clonogenic expansion within the primary tumor bulk. Thus, resolving both the specific cell of origin for prostate cancer and the interactions between the cells and the surrounding microenvironment within the cancer stem cell niche are crucial to appropriately define rational targets for therapeutic intervention and cure prostate cancer.

引用

页码：427 / 435

页数：9