Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases

被引：5
作者：
Aiello, Francesca [1 ]
Valacchi, Giuseppe [2 ]
机构：
[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy
[2] Univ Ferrara, Dept Life Sci & Biotechnol, I-44121 Ferrara, Italy
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2014年 / 14卷 / 22期
关键词：
Alzheimer; Antioxidants; Cancer; Cardiovascular diseases; Enzymes; Reactive oxygen species; SECRETORY PHOSPHOLIPASE A(2); 5-HT6 RECEPTOR ANTAGONISTS; INDUCED AIRWAY RESPONSES; TARGETING A-BETA; ALZHEIMERS-DISEASE; ANTITUMOR-ACTIVITY; LEUKOTRIENE BIOSYNTHESIS; TUBULIN POLYMERIZATION; BIOLOGICAL EVALUATION; KINASE INHIBITORS;
D O I：
10.2174/1568026614666141203142926
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The chemical versatility of the indole nucleus still inspires the pharmaceutical research to develop innovative suitable indole based drugs. The present work is an overview of the use and application of indole molecule based derivatives, as possible treatment in the main Oxidative Stress related diseases, such as cardiovascular, neurological, and cancer. The indole nucleus is a particular class of reducers, very efficient when bearing aliphatic substitutions in position 3, like that found in tryptophan (Trp). The principal chemical modifications carried out on the indole nucleus, were focused to obtain orally active drugs for a simpler delivery to the patients.
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收藏
页码：2576 / 2589
页数：14
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