Teicoplanin-induced hypersensitivity syndrome with a preceding vancomycin-induced neutropenia: a case report and literature review

被引：17

作者：

Hsiao, S. -H. ^{[2
]}

Chen, H. -H. ^{[3
]}

Chou, C. -H. ^{[2
]}

Lin, W. -L. ^{[2
]}

Liu, P. -Y. ^{[2
]}

Wu, T. -J. ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Internal Med, Tainan 704, Taiwan

[2] Natl Cheng Kung Univ Hosp, Dept Pharm, Tainan 70428, Taiwan

[3] Natl Cheng Kung Univ Hosp, Dept Surg, Tainan 70428, Taiwan

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2010年 / 35卷 / 06期

关键词：

cross-reactivity; drug hypersensitivity syndrome; neutropenia; teicoplanin; vancomycin;

D O I：

10.1111/j.1365-2710.2009.01124.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hypersensitivity syndrome associated with teicoplanin has rarely been reported. We report a case with a preceding episode of vancomyin-related neutropenia. A 47-year-old female with cervical spine infection was treated with vancomycin. Neutropenia occurred after 17 days of vancomycin therapy. Vancomycin was changed to teicoplanin, and the neutropenia resolved 4 days later. After 11 days of teicoplanin therapy, a new episode of hypersensitivity syndrome manifested as fever, bilateral neck lymphadenopathy, mild wheezing, hepatitis and increased CRP occurred. Neutropenia and thrombocytopenia developed 3 days later. The patient's symptoms settled over 1 week following withdrawal of teicoplanin. Naranjo's ADR algorithm categorized the neutropenia associated with vancomycin and the hypersensitivity syndrome associated with teicoplanin as 'probable'.

引用

页码：729 / 732

页数：4

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