Determination of Metformin Hydrochloride in Pharmaceutical Formulations

被引：0
|
作者：
Sharma, Vipin K. [1 ]
Bhattacharya, A. [1 ]
机构：
[1] Gurukul Kangri Vishwavidyalaya, Dept Pharmaceut Sci, Haridwar 249404, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2010年 / 22卷 / 10期
关键词：
Metformin hydrochloride; HPLC; Electrophoresis; Chemical derivatization; Diabetes mellitus; AMPLIFIED SAMPLE STACKING; HUMAN-PLASMA; CAPILLARY-ELECTROPHORESIS; LIQUID-CHROMATOGRAPHY; CHEMILUMINESCENCE DETERMINATION; QUANTITATIVE-DETERMINATION; PURE FORM; EXTRACTION; URINE; BIGUANIDES;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Metformin hydrochloride is an antidiabetic drug of biguanide category with multiple benefits in type II diabetes mellitus e.g., lowering of HbA(1c) values, lipid profile regulation and improvement in vascular and hemodynamic indices. Adverse effects are generally tolerable and self-limiting. Alone as well as in combination with other antidiabetic drugs of different categories, it is administered in different formulations. Due to short biological half-life (2-6 h), it is available in sustained release formulations. The present study concentrates on the various analytical methods of metfromin hydrochloride determination in dosage forms as well in blood plasma.
引用
收藏
页码：8273 / 8279
页数：7
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