The Effects of Lung-Moistening Herbal Medicines on Bleomycin-Induced Pulmonary Fibrosis Mouse Model

被引:4
|
作者
Ahn, Junmo [1 ]
Joo, Hyejin [2 ]
Park, Jihye [3 ]
Park, Jae-Woo [1 ]
Kim, Kwan-Il [1 ]
Jung, Hee-Jae [1 ]
Bu, Youngmin [1 ]
Lee, Beom-Joon [1 ]
机构
[1] Kyung Hee Univ, Coll Korean Med, Seoul 02447, South Korea
[2] Kyung Hee Univ, Grad Sch, Coll Sci Korean Med, Seoul 02447, South Korea
[3] Kyung Hee Univ, Grad Sch, Dept Biomed Sci & Technol, Seoul 02447, South Korea
基金
新加坡国家研究基金会;
关键词
pulmonary fibrosis; bleomycin; herbal medicine; broncho alveolar lavage fluid; inflammation; DIAGNOSIS;
D O I
10.3390/pr8010102
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
In traditional medicine, lung-moistening herbal medicines (LMHM) are regarded as a major option for treating symptoms of pulmonary fibrosis (PF) including dry cough and dyspnea. As PF agents are being applied to the development of lung cancer agents, PF and lung cancer are reported to have high pathological and pharmacological relationships. This study was proposed to identify candidates for the treatment of PF via investigating the effect of LMHM on PF mouse model. PF was induced by intratracheal instillation of bleomycin. Six water extracts of LMHM such as Farfarae Flos (FAF), Trichosanthis Semen (TRS), Lilii Bulbus (LIB), Adenophorae Radix (ADR), Asteris Radix (ASR), and Scrophulariae Radix (SCR) were prepared and administered (300 mg/kg) orally for 10 days after induction. The changes in body weight, histopathology, and immune cell of bronchoalveolar lavage fluid (BALF) were investigated. Among those, LIB and ADR significantly decreased the deposition of collagen and septal thickness of alveolar and terminal bronchiole. Moreover, SCR, TRS, LIB, and ADR decreased total cells, macrophages, and lymphocytes in BALF. Taken together, ADR and LIB could be the candidates to reduce PF. Further studies on their effects at different doses and analysis of their underlying molecular mechanisms are needed.
引用
收藏
页数:7
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