1,1-disubstituted tetrahydroisoquinolines from enaminones via Pictet-Spengler reaction

被引：10

作者：

Venkov, AP ^{[1
]}

Angelov, PA ^{[1
]}

机构：

[1] Paisij Hilendarski Univ Plovdiv, Dept Organ Chem, BG-4000 Plovdiv, Bulgaria

来源：

SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 17期

关键词：

enaminones; tetrahydroisoquinolines; cyclization; Pictet-Spengler reaction;

D O I：

10.1081/SCC-120022477

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enaminones, prepared by condensation of homoveratrylamine with 1,3-dicarbonyl compounds, undergo intramolecular cyclization in acidic media to afford 1,1-disubstituted tetrahydroisoquinolines in good yields. Further modification of the title compounds is demonstrated.

引用

页码：3025 / 3033

页数：9

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