Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets

被引：127

作者：

Sato, Ryo ^{[1
,2
]}

Semba, Takashi ^{[1
,3
]}

Saya, Hideyuki ^{[1
]}

Arima, Yoshimi ^{[1
]}

机构：

[1] Keio Univ, Inst Adv Med Res, Sch Med, Div Gene Regulat, Tokyo, Japan

[2] Kumamoto Univ, Dept Resp Med, Kumamoto, Japan

[3] Kumamoto Univ, Dept Thorac Surg, Kumamoto, Japan

来源：

STEM CELLS | 2016年 / 34卷 / 08期

关键词：

Cancer stem cell; Epithelial-mesenchymal transition; Tumor heterogeneity; Therapeutic resistance; GROWTH-FACTOR RECEPTOR; TRANSCRIPTION FACTORS SNAIL; GENE-EXPRESSION SIGNATURE; LYMPH-NODE METASTASIS; E-CADHERIN; PROSTATE-CANCER; UP-REGULATION; SELF-RENEWAL; ALDEHYDE DEHYDROGENASE; CLINICAL-SIGNIFICANCE;

D O I：

10.1002/stem.2406

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cancer stem cells (CSCs) constitute a small subpopulation of cancer cells with stem-like properties that are able to self-renew, generate differentiated daughter cells, and give rise to heterogeneous tumor tissue. Tumor heterogeneity is a hallmark of cancer and underlies resistance to anticancer therapies and disease progression. The epithelial-mesenchymal transition (EMT) is a reversible phenomenon that is mediated by EMT-inducing transcription factors (EMT-TFs) and plays an important role in normal organ development, wound healing, and the invasiveness of cancer cells. Recent evidence showing that overexpression of several EMT-TFs is associated with stemness in cancer cells has suggested the existence of a link between EMT and CSCs. In this review, we focus on the roles of CSCs and EMT signaling in driving tumor heterogeneity. A better understanding of the dynamics of both CSCs and EMT-TFs in the generation of tumor heterogeneity may provide a basis for the development of new treatment options for cancer patients.

引用

页码：1997 / 2007

页数：11

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